306 results
We hypothesize that depletion of carnitine occurs during infusion of oxaliplatin, due to increased renal loss. This secondary carnitine deficiency may contribute to the development of CIPN.
We hypothesise that the diet over time has become healthier and more sustainable. Our current study was set up to (1) identify the differences in food consumption and nutritional quality over the course of 20 years in the Netherlands using the…
Submucosal irrigation with the Gum Irrigator will reduce bleeding on probing, pocketdepts and the amount of anearobic bacteria in the non-surgical treatment of peri-implantitis.
To compare the resection speed of two different devices for removal of polyps (≥8mm - ≤20 mm) in terms of efficiency and complications.
We hypothesize that the associations between biopsychosocial factors and post-TBI sleep complaints and fatigue change over time., i.e., that the associations with biological factors are strongest in the first six months and then decline, whereas the…
Routine admission to the ICU after pulmonary surgery may not necessarily be required for each patient. The aim of this study is to identify which patients may benefit from admission to the ICU after pulmonary surgery and to develop a clinical…
Our hypothesis is that despite advanced laboratory techniques serum levels of amylase/lipase are <3 times ULN in patients presenting with hypertriglyceridemia during acute pancreatitis.
Since progression from NAFLD to NASH is associated with significantly increased risk of morbidity and mortality, there is a clinical imperative to identify the NAFLD patients that rapidly progress to NASH from those who will remain in the NAFLD…
The main objective of this study is to compare upper extremity dysfunction (UED) following slender TRPCI using small bore catheters (5F) compared to standard PCI using regular size guiding catheters (6F) and conventional stent techniques at two…
Tacrolimus (FK506) is the main immunosuppressant that is prescribed after kidney transplantation. One of the disadvantages of Tacrolimus is the small therapeutic window. In transplantation patients therapeutic drug monitoring is routinely performed…
The primary hypothesis is that a novel clinical decision rule for pulmonary embolism (the YEARS strategy) is at least as safe as previous studies, yet with an increased proportion of patients safely not referred for CTPA, thus fewer false-positive D…
It is hypothesized that FAME has a positive impact on family functioning and prevents further development of parental symptoms of anxiety and depression.
Obesity is significantly associated with Atrial Fibrillation (AF), and, interestingly, if obese patients loose weight, AF dissapears in 50% of the cohort. On the other hand, adipose tissue (AT) functioning alters up weightchange. Therefore we…
Ex vivo organoid response correlates to in vivo response to standard first line treatment in mCRC patients on a metastasis level, therefore organoids can be used to predict response to therapy and select patients for a specific treatment.
By means of image-guided surgery, we can navigate the procedure by visualization of pre-operative planned MR and/or CT based 3D models and providing the surgeon with real-time feedback on the position of the surgical tool within this model and more…
The adherence of NOACs in atrial fibrillation in specific subgroups is low. Identifying these non-adherent patients in daily clinical practice is important to minimise stroke and bleeding risk. We hypothesize that NOACs are relatively often…
Being diagnosed with prostate cancer impacts patients quality of life. Besides choosing a treatment strategy that suits patients' values and preferences, they may look for subsequent strategies to cope with their disease. Dietary changes may…
The main objective of this study is to evaluate the efficacy of the blended eHealth cognitive behavioural intervention as an additional treatment to treat insomnia (e-CBT-I) in people with acquired brain injury. The main research questions are: 1…
We hypothesize that socioeconomic inequalities in diet quality are partly explained by differential dietary costs.