343 results
The aim of this research is developing a non-invasive a method of early detection of CIS using scrotal ultrasound and semen diagnostic on CIS-cells. The results of this research will be used for the set-up of a screening study of CIS at men with an…
To describe the prevalence of enteropathogenic viruses in children with primary (CVID and CVID-like disease) and secundary immunodeficiencies and a potential relation between this prevalence and the development of auto-/allo-immune enteropathy.
The goal of this study is to find an efficient early diagnostic and prognostic marker of myocardial ischemia and myocardial infarction. Extended screening of gene expression profiles in circulating progenitor cells in the peripheral blood of…
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
Objective: The primary goal of the current study is to study the immunogenicity and safety of HPV vaccination in patients with an autoimmune disease. Based on retrospective analysis with other vaccines we hypothesize that patients with autoimmune…
To develop non-invasive markers for tissue changes in skeletal muscle using MR methods
The proposed study aims to develop a prediction rule for response to biological treatment in RA (i.e. effectiveness and adverse events). Guidelines for treating the disease with biologicals using the (derived) prediction rules will be defined. To…
Conditions that promote IL-10 producing B cells in humans are still ill defined. In this project our aim is to investigate the frequnecy of IL-10 producing B cells in healthy volunteers. Next, we aim to compare this to the frequency of IL-10…
With this prospective registry we aim to evaluate the outcome of patients with a T2-T3 primary melanoma and minimal SN tumor burden, treated by CLND or nodal observation:* The main objective is to determine if T2-T3 melanoma patients with minimal SN…
The goal of this pilot study is to (i) investigate which measurements are suitable best for the evaluation of (cost) effectiveness, (ii) investigate whether CAT can be given as a nursing intervention (feasability).
This current study aims to investigate the use of Curios bèta-TCP, a synthetic tricalcium phosphate for repair of the alveolar cleft in patients with clefts of lip, alveolus and palate.The specific properties of Progentix TCP result in optimal and…
The primary objective of the study is to assess the effect of missed doses of atomoxetine and OROS methylphenidate in ADHD patients who are stable on pharmacotherapy based on the patient*s daily behavior as assessed by the Daily Parent Report of…
In this study we aim to examine the relationship between certain potential risk factors and the development of Parkinson Disease: environmental exposure to pesticides, exposure to extremely low frequency electromagnetic fields, and the role of…
The aim of this study is to compare the time course of cytokines (markers for inflammation) in the following 3 groups: RSV-positive, ventilated patients; RSV-positive, non-ventilated patients and RSV-negative, ventilated patients. The main…
To study the relationship between (a) abnormal concentrations of plasma amino-acids, pterins, HVA and inflammatory parameters and (b) the severity, duration and outcome of delirium. To find a biochemical profile that predicts the occurrence of a…
To study if there is a role for prophylactic VZV vaccination prior to transplantation to boost the patients B- and T-cell repertoire and thereby reducing the incidence and morbidity associated with herpes zoster.
1. Does mPAT directly impair vasoreactivity to insulin and acetylcholine ex vivo in arterioles obtained from muscle biopsy in lean and obese individuals?2. Is obesity in humans associated with the accumulation of mPAT and an inflammatory mPAT…
The main objective of this study is to increase current insights into the role of auditory and cognitive factors in the reduced ability to understand speech in noisy environment, particularly for hearing impaired people. These insights will help to…
(1) To asses the influence of P-gp function at the BBB on flumazenil binding to the GABAA-receptor in pharmacoresistant patients with temporal lobe epilepsy (TLE), using PET and [11C]flumazenil as a ligand and tariquidar as P-gp blocker. (2) If we…
The objective of this study is threefold. The first objective of the study is to determine the course of pervasive developmental disorders (more specific PDD-NOS) and thought problems (more specific MCDD). Secondly, possible processes underlying…