970 results
The proposed study aims to develop a prediction rule for response to biological treatment in RA (i.e. effectiveness and adverse events). Guidelines for treating the disease with biologicals using the (derived) prediction rules will be defined. To…
To investigate whether children with OI who use a wheelchair (for long distances) can reliably perform a valid shuttle ride test in order to assess the levels of health-related fitness in this group.
Primary Objective:Proof of concept study designed to document the safety and feasibility of adjuvant treatment with the PICSO Impulse system in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) treated with primary PCI…
Theoretically the anatomical reconstruction technique should give better results in rotational stability due to a more anatomical placement of the ACL-graft. Though it is difficult to test this correlating to functional outcome, because in current…
The objective of the study is to examine characteristics in brain function, structure, hormonal response, genetic makeup and heart rate variability specific for resilience to stress
To compare the feasibility and safety of surface cooling to 34, 34.5, and 35*C, started within 4.5 hours after the onset of acute ischaemic stroke and maintained for 24 hours, in awake patients on a stroke unit.
The main of objectives are to study the effect of the start of dialysis treatment (hemodialysis and peritoneal transplantation), on selected cardiovascular, nutritional parameters as well as physical activity. Secondly, a differentiation will be…
1. What is the complication rate of the initial antibiotic treatment strategy for acute simple appendicitis (radiological proven) in children aged 7-17 years old?
To investigate the effect of cholic acid supplementation on the clinical and biochemical parameters of Zellweger spectrum disorder
To develop non-invasive markers for tissue changes in skeletal muscle using MR methods
To confirm previous study results using a Solace Balloon and to support future marketing efforts in the European Union and provide data for publications.
To evaluate the effects of intravenous iron suppletion in iron deficient PAH patients.Amendment: to compare exercise capacity and isolated muscle strength in IPAH patients and healthy controls
To investigate the feasibility of SDF imaging and spectrophotometry of the vaginal wall.
The goal of this trial is to collect long-term observational data on the tolerability, safety and efficacy of dabigatran etexilate in a spectrum of patients receiving bileaflet mechanical heart valves. All patients that have completed study 1160.113…
A. Determine the placement of the Maple-probe in relation to the anatomy of the pelvic floor musculature.B. Determine the normal rest tone of the pelvic floor musculatureC. Determine the normal activity of the pelvic floor musculatureD. Determine…
To study the potential of baclofen as an anti-craving/relapse agent in GHB dependent patients.
Run-in phase I: To confirm the safety and tolerability of BIBF 1120 up to a dose level of 200 mg b.i.d added to a standard dose of cisplatin/gemcitabine in first line NSCLC patients with squamous cell histology. Pharmacokinetics of BIBF 1120 and…
The aim of the main study is to compare the effects of MR30365/07 and fentanyl on ventilation and analgesic responses to noxious electrical and heat stimulation in healthy volunteers, by performing pharmacokinetic / pharmacodynamics (PK/PD) modeling…
The purpose of the study is to compare the hemodynamic effects (study of blood flow or circulation, such as blood pressure, heart rate, cardiac output (the volume of blood being pumped by the heart) and glomerular filtration rate (flow rate of…
The purpose of this study is to confirm/validate predicted dabigatran trough plasma levels gained after individual dose assignment based on simulations by means of PK data from the RE-LY trial. Based on this validation a final appropriate dosing…