40 results
To assess the PK/PD relationship of prednisolone as either prophylaxis or therapy of GVHD in children after HCT.
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
We hypothesize that functional Near Infrared Spectroscopy (fNIRS), eye-tracking, Indirect Calorimetry (IC), the BOD POD, and Bio-Impedance Analysis (BIA) are feasible outcome measures for children with Angelman syndrome.
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene expansion carriers on negative medication effects of HD-related medication with an actionable drug-gene interaction in the…
The experimental treatment (game-supported TPM training) will contribute to a more effective generalisation of compensatory strategies to untrained tasks as compared to the active control group (CogniPlus training).
Action research in which the intervention will be developped trough short-cylce evaluation rounds by the research team together with an expert panel. The initital intervention has been designed based on scientific literature review, practical…
Virtual reality hypnosis is similarly effective in comparison to conventional medical hypnosis in reduction of pain and anxiety throughout needle related procedures in children in a clinical setting.
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
The quality of life of adult patients with NMD can be enhanced by providing capability care in comparison to usual care.
To determine the musculoskeletal safety of standard prophylactic treatment with ciprofloxacin and co-administered glucocorticoids in pediatric patients with acute lymphoblastic leukemia (ALL).
Tones vs. neutral self-voice (EEG experiment 1 in Session 3; Pinheiro et al., 2018): a) no effect of HP on N100 suppression for self- and externally generated tones as we would expect alterations in sensory feedback only with regards to one’s own…
Vitamin C deficiency may play a role in the symptoms of patients with chronic kidney failure and eventually renal replacement therapy
As changes in gutmicrobiota composition could play a role in the development of autoimmune diseases including hypothyroidism, we will investigate whether repetitive fecal transplantation from either allogenic (healthy) or autologous (own) fecal…
To determine the content validity and clinical utility of the Dutch sPCI according to nurses with expertise in stroke care and stroke patients, respectively.
This research aims to determine factors involved in subfertility and serious pregnancy complications that arise early in pregnancy. Due to increased insight into the pathogenesis of these conditions, primary prevention should ultimately be possible.
We hypothezise that patients with a primary tumor expressing ER and lacking HER2 but with CTCs expressing HER2 have a worse response on hormonal therapy.
To assess the PK/PD relationship of prednisolone regarding toxicity as clinical outcome in paediatric patients with autoimmune or autoinflammatory diseases
This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…
To establish the diagnostisch accuracy of ultrasound for the exclusion of fracture of the elbow
The hypothesis investigated is that a correct diagnosis (including subclassification of the tumor) and prognosis can be made more rapidly and that monitoring tumor development in response to therapy is more precise when adding tumor markers to the…