622 results
We expect that the disproportionally strong clinical effects of fingolimod in relapsing remitting multiple sclerosis can be explained by enhanced functional adaptation mechanisms of the brain and that enhanced functional adaptation will be sustained…
The incidence of pulmonary embolism at autopsy in cancer patients is substantial
In this pilot study we want to look at different aspects of radiation damage, including effects on microvasculature, blood-brain barrier function and white matter changes. We hypothesize that combining these different imaging modalities (MRI and PET…
Oral deuterated water dosing can be used in septic ICU patients to study long-term diurnal muscle protein synthesis rates
Peanut allergy is a common disease, may be lifelong and may be severe. Like other allergic diseases, the prevalence of peanut allergy has increased during the last few decades. Food allergy develops as a consequence of a failure in oral tolerance,…
To dermine the kinetics and spectrum of tumor mutations in the urine and plasma of bladder cancer patients receiving neoadjuvant chemotherapy for locally advanced cancer or systemic therapy for metastatic disease.
We hypothesize that in current dermatological practice, there is a undisclosed burden of psoriatic arthritis in psoriasis patients. We wish to discover the prevalence of known and unknown arthritis in these patients, and find clinical and…
Health outcomes for people at risk of or suffering from non-communicable lung diseases in low-resource settings will be improved by developing capacity for implementation of evidence-based interventions for prevention, diagnosis and treatment in…
We expect that planned visits at the outpatient clinic are unnecessary due to low percentage of treatment changes. Furthermore, we expect that treatment changes will appear at unplanned visits.
PD-L1 is up to now the only marker that has been validated for the selection of patients treated for non-small cell lung cancer who might benefit from the treatment with PD-1/PD-L1 inhibitors. Thus far, PD-L1 status is assessed with histology, being…
Based on clinical experience in our multidisciplinary team caring for children with PAH and CHD, we expect that children with PAH and their families suffer from decreased psychosocial QoL compared to healthy norms. We expect psychosocial…
Implementation of Syncope Algorithms (SAs) in the Netherlands will increase diagnostic yield, avoid unnecessary admissions and improve quality of life (QoL) by offering timely diagnosis & treatment
We hypothesize that remote home monitoring can detect post-discharge complications early and might prevent hospital readmissions.
The CPCHILD-18+ is sufficiently tested for its psycometric characteristics to be used in clinical practice and research
Self-paced treadmill walking increases the energetic cost of walking and is related to the variability of biomechanical and spatiotemporal parameters and muscle activation patterns.
In this epidemiologic study a cohort of patients with MFT transferred and/or referred to the National Hospital of Odonto-Stomatology Ho Chi Minh City (NHOS-HCMC), Vietnam, was analyzed following the MFISS and FISS protocol. This study will give a…
An intervention aimed at improving recovery during work will lead to less fatigue in shiftwork employees.
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals