306 results
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
To study the differences in adipose tissue, liver and circulating levels of RBP4 in lean versus obese, diabetic and obese insulin, non-diabetic subjects in relation to glucose fluxes and hepatic triglyceride content
The main objective of this study is to measure the effects of the monitoring and feedback tool embedded in a Self-management Support Program on physical activity. The secondary objective is to measure the effect on self-efficacy, quality of life and…
To investigate causes and predictors for primary or secondary allergy profiles for soymilk
To demonstrate differences in neuronal structure and neuronal function in brain regions that control eating behaviour between obese and normal weight adolescents.
Is recurrent miscarriage an independent risk factor for an increased cardiovascular risk?
The major objectives are to investigate if a prolonged exercise training program can lower the intrahepatic lipid content and can improve the metabolism of the liver in type 2 diabetic patients and patients with non-alcoholic fatty liver disease,…
The main objective of the study is to quantify mitochondrial dysfunction in vivo and obtain information of molecular scale adaptations of the muscle cells that potentially underlie the observed dysfunction. The mathematical model will be applied to…
This study investigates to which degree osteoporosis patients taking weekly oral bisfosfonate medication are influenced by by three telephone support calls during the first year after starting this medication.To verify the results of patients` self…
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
The main objective of this study is to test whether cognitive behaviour therapy delivered by internet has a significant effect on fatigue in patients with type 1 diabetes en whether this effect is sustained during a follow-up period of six months.…
The aim for this study is to investigate feces composition and postprandial effect, as done with oral fat loading test (OFLT), on endotoxemia (e.g. LPS and Ralstonia levels) in plasma as assessed with qPCR.
Hypertension is characterized by vascular remodelling and endothelial dysfunction. Sphingolipids such as ceramide and sphingosine-1-phosphate may play an important role in regulation of vascular contractility and tonus. In this study the altered…
The aim of this study is to investigate if changes in vascular compliance in children with type 1 diabetes are related to endothelial markers and to changes in skin AGE and to investigate whether patients at risk to develop cardiovascular disease…
Pilot study to test the feasibility of measuring glucose uptake in adipose tissue under hyperinsulinemic hypo- ande euglycaemic conditions to quantify the effect of hypoglycaemia on metabolic activity of adipose tissue (VAT, SAT and GFAT) in…
The aim of the present research proposal is to metabolically phenotype endurance trained athletes, lean and obese sedentary and type 2 diabetic individuals with the following objectives:(1) To assess metabolic flexibility as measured by a euglycemic…
We hypothesize that impaired insulin uptake into skeletal muscle interstitium (thus decreased transendothelial transport of insulin) is impaired in patients with type 2 diabetes mellitus. This hypothesis will be addressed in the present study.
To investigate the differences in short-chain fatty acid metabolism, markers of local (intestinal) and systemic inflammation and markers of bacterial translocation between type-1-diabetes patients and healthy controls and to relate these differences…
Primary Objective:To investigate the feasibility of studying of the effects of 6 days of predominantly prolonged sitting on cardiometabolic health in young adults.Secondary Objective: To collect preliminary data on the effects of 6 days of…
Aim of our study is to investigate the influence of HPT secondary to moderate-severe vitamin D deficiency and vitamin D replacement on the coagulation and fibrinolysis system