624 results
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
The objective of the study is to examine characteristics in brain function, structure, hormonal response, genetic makeup and heart rate variability specific for resilience to stress
Our primary objective is to investigate the development of structural and functional connectivity in autism and ADHD in comparison to the typical development of connectivity. A secondary objective is to investigate the effects of ADHD and autism…
If normal doubt occurs, will OCD patients differ from non-OCD anxiety patients and healthy controls in how much uncertainty they will experience and will OCD patients respond to this with more perseveration (chekcing behavior) than non-OCD anxiety…
The two primary objectives are to test the hypothesis that (1) structural and functional abnormalities of the fronto-striatal circuits are related to the development of compulsive and impulsive behaviour in ASD and OCD; and that (2) the glutamate…
To compare sex differences in brain functioning using functional magnetic resonance imaging (fMRI) in healthy pre-pubertal boys and girls with a group of children diagnosed with GID. Subjects will have a second fMRI scan, as soon as they enter…
The present study will test 1) whether childmolesters (including childpornography downloaders) show ASD symptoms, like disturbances in recognizing other*s emotions, feelings, intentions and thoughts, lack of interpersonal skills empathy deficits and…
To study the relation between face processing and activation in cortical pathways in adults with Autism Spectrum Disorder.
Objective: Our general objective is to investigate the neurobiological substrates of a broader ADHD phenotype.
1. We will recruit 30 probands who meet DSM-IV inclusion criteria for a primary psychotic disorder or mood disorder with psychotic features: schizophrenia, schizoaffective disorder, delusional disorder, bipolar I disorder, psychotic depression, post…
1) To study the predicitve value of fear acquisition and extinction mechanisms on treatment outcome in anxiety disordered patients. 2) To study pathological fear acquisition and extinction in anxiety disorders: what are the differences in…
This study focuses on collecting data on knowledge, attitudes, skills, experiences and needs related to sexuality and relational functioning in high-functioning Dutch boys with autism between 15 and 18 years old (up to and including 17). Data are…
In this project, I wish to take a novel step in understanding the influence of environmental exposures in the aetiology of psychotic disorders, by studying occurrence of (minor) psychotic symptoms and the (correlates of) physiological indicators of…
Primary: a) To asses whether there is a difference in patients with major depression and healthy controls in serotonin synthesis rates. Secondary: a) Do these rates correlate with severity of depression? b) Does serotonin synthesis correlate with…
The aim of this project is to elucidate the mechanisms underlying one of the most incapacitating psychiatric disorders, psychosis. Despite antipsychotic treatment, up to a third of patients with psychotic illness continue to experience significant…
The primary goal of this project is to study whether children with ADHD differ from the normal population on the urinary and plasma levels of the AAA*s (tryptophan, tyrosine and phenylalanine) that are related to the functioning of serotonin and…
The present study has the following objectives:1) Investigating the clinical utility of screening instruments. As a part of this objective, we will examine how several demographics (e.g. ethnicity) affect the assessment of autistic and other…
The primary objective of this study is to evaluate neurophysiologic changes of the pain centres of the brain (the differences in particular in the thalamus, primary and secondary somatosensory cortex, insula, anterior cingulate cortex and the motor…
The main goal of this study is to establish the reliability (internal consistency and interrater reliability) and validity (discriminant, contruct and predictive validity) of the INCAS. Differences between the SMI and healthy group will be studied (…