396 results
To investigate what the ideal moment to vaccinate would be, early (after 2-6 months) or late (after 9-12 months) after cessation of rituximab. Secondly to study the immune-response to vaccination with influenza virus vaccine after treatment with…
The primary objective of this study is to determine the impact of a diagnosis and type of treatment of cancer, ageing and their interaction on wellbeing of older cancer patients. Furthermore, we aim to determine the different psychosocial…
To investigate the release of damage-associated molecular patterns (DAMPs) following major hepatic resection with or without VIO and to correlate the outcomes to the acute inflammatory response and clinical parameters for hepatocellular damage.
The overall objective of the MOBI-KIDS study is to assess the potential carcinogenic effects of childhood and adolescent exposure to RF and ELF from mobile telephones on the central nervous system (CNS). In order to achieve the overall objective,…
The aim of our study is to assess the prevalence of cardiac dysfunction and undiagnosed heart failure in women registered in general practice with a history of breast cancer who received chemotherapy and / or radiotherapy as compared to a matched…
The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…
Our primary hypothesis is that the process of nasopharyngeal and fecal colonization from birth to childhood differs in quality and quantity between infants with CF and healthy controls and that these differences are related to subsequent respiratory…
We will examine the activation status of platelets, the content of platelet granules, and activation of de novo synthesis of mitogenic proteins during and after a partial liver resection in patients with a malign or benign tumor including distant…
Run-in phase I: To confirm the safety and tolerability of BIBF 1120 up to a dose level of 200 mg b.i.d added to a standard dose of cisplatin/gemcitabine in first line NSCLC patients with squamous cell histology. Pharmacokinetics of BIBF 1120 and…
The trial aims to investigate whether procalcitonin measurements can reduce the amount of blood cultures in the ICU safely and cost-effectively.
Primary Objective: 1) To study impairment and developmental delay in social cognition (and related cognitive functions) caused by brain damage in patients treated for a brain tumour in childhood as compared to a reference group of chronically ill…
This research aims to assess the effect ofn completing an ACA-task on decision-making regarding short-course pre-operative radiotherapy in the treatment of rectal cancer in clinical practice.
Of note, the objectives and end points described below all refer to in vitro assessments. The only patient intervention is the removal of peripheral blood in order to provide samples for the in vitro tests. First Objective: Development of a human,…
To study prevalence and consequences of cognitive, psychological, social and functional decline in elderly breast cancer patients, in comparison to a population elderly without breast cancer.
A phase Ib / II randomized study of BI 836845 in combination with exemestane and everolimus versus exemestane and everolimus alone in women with locally advanced or metastatic breast cancer.With following objectives:Phase Ib part: To determine the…
Objective: The primary goal of the current study is to study the immunogenicity and safety of HPV vaccination in patients with an autoimmune disease. Based on retrospective analysis with other vaccines we hypothesize that patients with autoimmune…
This study examines the effect of systematic geriatic screening, via a geriatric oncology care module and geriatric interventions, on the quality of life of patients aged 70 years or older with colorectal carcinoma. We also examine whether…
The objective of this study is to examine the vestibular system in three dimensions. To achieve this goal three experiments are performed. The EyeSeeCam video-oculography is validated with the scleral search coils (international golden standard).…
Main objective is to investigate whether the use of a modified CellSearch enrichment for the enumeration of pleural effusion tumor cells (PTCs) is able to increase sensitivity of pleural effusion evaluation in MPM, as compared to standard…
The objective of the study is to identify potential platelet-derived angiogenic and angiostatic tumorbiomarkers. Initially platelet proteomics will be used to detect potential tumormarkers. Subsequently, these potential tumorbiomarkers will be…