307 results
To determine the frequency of MBL and FCN SNPs in patients with a history of a proven gram-positive bacteremia, compared to patients without such history. A secondary objective is to determine whether extracorporeal circuits, used in cardiothoracic…
• To increase the sensitivity of the current MRI methods for detecting the changes caused by NPSLE through the scans made on the 7 Tesla scanner, since the higher field strength will lead to a higher signal to noise ratio and higher resolution. • To…
This research aims the usefullness of duplex mapping in systemic giant cell vasculitis. In determing the diagnosis, the duplex will be compared with the current gold standard, the 18F-FDG PET-CT, looking at the sensitivity and specificity of the…
Aim of the project1) To detect cerebral structural changes in SSc patients.2) To investigate the influence of chronic inflammation and chronic vasculopathy on the cerebral metabolismand haemodynamic function in SSc patients.3) To correlate the MRI…
The objectives of this study are to determine the prevalence of dRTA, osteoporosis and nephrolithiasis in patients with SS. We also try to elucidate the mechanism which is responsible for developing dRTA in patients with SS. The role of auto…
To investigate the impact of high field 3T MRI on the diagnostic criteria in MS in a large multicenter study population using multiple vendor MRI systems.
The main objective of the study is to investigate whether the strong clinical effects of natalizumab in RRMS can be explained by enhanced functional adaptation mechanisms of the brain and whether enhanced functional reorganisation is sustained over…
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
To define differences in the molecular composition of human milk extracellular vesicles between allergic and non-allergic mothers. Additionally, other differences in human milk composition will be analyzed (cellularity, nutrient content,…
The aim of the study is to identify patients with selective gamba-allergy and sensitization patterns for the various allergens in gamba extracts. Comparing sensitization patterns between patients who clinically react to Gamba with patients having a…
This project aims at documenting long-term disease outcome and quality of life of patients with cSLE in the Netherlands.
Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…
The main hypothesis is that circulating inflammatory mediators are the main causative factor for the emergence of generalized osteoporosis in patients with Rheumatoid Arthritis (RA). 1.Does the serum of patients with active RA, containing…
Our objective is to assess whether patients with SM compared to controls have more advanced atherosclerosis assessed by carotid intima-media thickness (C-IMT) and carotid plaques and have a more adverse cardiovascular risk profile.
To perform a comprehensive analysis of the cellular infiltrate in lesional AD skin, using state of the art immunohistochemical techniques.
Has the supplementation of oligosaccharides in the first year of life an effect on the incidence of atopic diseases and infections from the 5th until the 7th year of life in healthy children
To investigate the differences in short-chain fatty acid metabolism, markers of local (intestinal) and systemic inflammation and markers of bacterial translocation between type-1-diabetes patients and healthy controls and to relate these differences…
To answer the following questionsDo RA-specific autoantibodies cross the placenta, and can they be found in fetal cord blood in the offspring of mothers suffering from RA?Do RA-specific autoantibodies in fetal cord blood display different…
In this project we will perform lymph node tissue analyses in 1) autoantibody-positive individuals who are at risk of developing RA, 2) early arthritis patients who do (RA) or do not (yet) (unclassified arthritis, UA) fulfil 2010 ACR/EULAR…
Primary objective: To evaluate the influence of pSS on sexual function, as measured by the female sexual function index (FSFI), in comparison to a healthy control group. Secundary objective: To evaluate the influence of pSS on subdomains of sexual…