334 results
The main objective of this study is to explore two novel MRI techniques to characterize myocardial properties that are expected to be useful for the diagnosis of various forms of cardiomyopathy. Furthermore, we will explore whether different stages…
The main objective of the study is to document cardiovascular dysfunction found in rheumatoid arthritis and gout patients using cardiac imaging techniques echocardiography and cardiac MRI.
Primary Objective:Proof of concept study designed to document the safety and feasibility of adjuvant treatment with the PICSO Impulse system in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) treated with primary PCI…
To quantify the impact of the use of the HEART risk score on patient outcome (major adverse cardiac events(MACE) and quality of life) and on costs in patients with chest pain presenting at the emergency room.
To gain a better insight into the genetic factors that play a role in the etiology of the thoracic aortic aneurysm with the following specific aims:1. Study of specific geneitc factos that play a role in the pathogenesis of both syndromic and non-…
The aim of our study is to assess the prevalence of cardiac dysfunction and undiagnosed heart failure in women registered in general practice with a history of breast cancer who received chemotherapy and / or radiotherapy as compared to a matched…
The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…
2. STUDY OBJECTIVESSpecific Aim 1. To determine whether Tako-Tsubo cardiomyopathy is associated with hyper reactivity of the neurohormonal and cardiovascular systems. Hypothesis 1: Patients with a clinical history of Tako-Tsubo cardiomyopathy have…
1) identifying new predictors of ST, in particular of late and very late ST and drug eluting stent thrombosis2) to observe clinical outcome after an episode of a ST
The goal of this trial is to collect long-term observational data on the tolerability, safety and efficacy of dabigatran etexilate in a spectrum of patients receiving bileaflet mechanical heart valves. All patients that have completed study 1160.113…
The goal of this study is to find an efficient early diagnostic and prognostic marker of myocardial ischemia and myocardial infarction. Extended screening of gene expression profiles in circulating progenitor cells in the peripheral blood of…
This study will address the mechanisms of DHF by identifying the role of biomarkers in the process of neurohormonal activation, cytokine activation and oxidative stress, the role of biomarkers at myocardial level in the process of cardiomyocyte cell…
The main objectives are 1) is to evaluate the prevalence of cardiac complications long-term after ASO by investigation of cardiac function as well as clinical outcome and to determine which factors (associated with life style or operative techniques…
The purpose of this study is to confirm/validate predicted dabigatran trough plasma levels gained after individual dose assignment based on simulations by means of PK data from the RE-LY trial. Based on this validation a final appropriate dosing…
To perform a human study demonstrating a detailed analysis of electrical and mechanical activation under different cardiac pacing conditions and to describe the accompanying hemodynamic response.Objectives:To demonstrate non-invasive mapping…
The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia
To determine: 1) the incidence of type 2 diabetes mellitus in FCHL patients, normolipidemic relatives and their spouses2) the incidence of cardiovascular disease in FCHL patients, normolipidemic relatives and their spouses3) the prevalence of CESD…
To investigate whether children with a history of Kawasaki disease have an increased IMT and arterial stifness compared to their healthy siblings.
To evaluate the clinical usefulness of the VU-AMS in pediatric cardiology.To validate and improve the measures of stroke volume from the VU-AMS device in a clinical population. VU-AMS stroke volume measures will be compared with stroke volume…
To assess the impact of six IV infusions of 3, 6, or 12 mg/kg of CER-001 or placebo, given at weekly intervals, on atherosclerotic plaque volume, as measured by coronary IVUS.