102 results
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
1. Are there differences between patients and controls in circadian movement rhythmicity and sleep duration?2. Are these objective measures associated with subjective sleep complaints?3. Are these objective measures associated with decreased quality…
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.
Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…
In order to confirm and externally validate the novel panel of genes identified in our study (06/101/K) to be significantly predictive of recurrent implantation failure, we will recruit 50 additional subjects treated by IVF who have undergone at…
Aim of our study is to investigate the influence of HPT secondary to moderate-severe vitamin D deficiency and vitamin D replacement on the coagulation and fibrinolysis system
To investigate the effect of resistance to thyroid hormone (RTH) due to a TRβ mutation on coagulation and fibrinolysis
ObjectiveThe main goal of this investigation is to evaluate the thyroid hormone response in patients with TMNG and control subjects in response to various pharmacological and physiological stimuli, administered according to the dynamic exposure test…
This observational cohort study is designed to evaluate the prevalence of acquired von Willebrand*s syndrome in patients with a new diagnosis of overt hypothyroidism.
The objective of this observational study is the safe introduction of clinical applied IVM in The Netherlands. During this study, the number and quality of the oocytes and embryos will be studied as well as pregnancy development. Emphasis will be on…
Our main aim is to describe the 24-h circadian rhythm of skin and core body temperature in people with SCI and examine whether changes in melatonin and/or cortisol relate to the altered circadian rhythm in core body temperature recently described in…
The primary objective of this clinical controlled trial is to define the overall effect of adenocorticotropic hormone on coagulation parameters in patients with primary adrenal insufficiency (as diagnosed by their physician by previous short ACTH…
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Whether cognitive functions in SGA children are impaired due to inappropriate developmental outgrowth in children born with a low birth weight is unknown. This is also the case for the fact whether GH treatment from the age of 4 years is still…
Protocol 1: To determine whether pituitary dysfunction is present at intermediate duration of follow-up after traumatic brain injuryProtocol 2: To determine whether injury to brain tissue that explains traumatic brain injury-induced pituitary…
We aim to investigate thirst in the above mentioned patient groups, applying a Visual Analogue Scale (VAS) and, where ethically acceptable, a new thirst provocation test which we will develop in a group of healthy probands. Using these tools, we aim…
Objectives: Part 1) To assess the prevalence of PA in general practice (part 1 of this study);Part 2) To describe differences of cardiorenovascular damage in newly diagnosed hypertensive patients with versus without PA (part 2 of this study);Part 3…
Objective: Main objective of this study is to compare the area under the MPH saliva concentration versus time curve (AUC) following ingestion of immediate and sustained release formulations of MPH in children with ADHD. Secondary objectives are: 1.…
To identify some of the mechanisms in patients in remission of Cushing*s syndrome that contribute to the persistence of visceral obesity, systemic inflammation, insulin resistance, sarcopenia, a low muscle oxidative capacity and increased risk of…