106 results
With this study, we aim to evaluate precision and practicability of three new measurements for (venous) Hb, as compared with the present standard.* Precision will be studied as sensitivity and specificity of the measurements for a venous Hb under…
The primary objective of this study is to investigate the effect of food on the pharmacokinetics(PK) of olaparib following oral dosing of the tablet formulation in patients with advancedsolid tumours.The secondary objectives are to investigate the…
The primary objective of this study is to investigate the effect of itraconazole on thepharmacokinetics (PK) of olaparib following oral dosing of the tablet formulation inpatients with advanced solid tumours.The secondary objectives are: to…
The primary study objective is to evaluate the Model 106 VNS Therapy® System cardiac-based seizure detection and Automated Magnet Mode (AMM) stimulation in epilepsy patients. These two new features will be evaluated using continuous observational…
Primary Objective: * Is CBM-I successful in changing the cognitive bias in patients with cluster-C personality disorders or personality disorder NOS?Secondary Objective(s): * Will patients following CBM-I show a significant reduction in symptoms and…
The main objectives of the present study are to examine the feasibility, efficacy and safety of intensive PE treatment within DBT for patients who have PTSD and a comorbid BPD.
To establish the validity of the self-report version of the AVHRS-I interview, the AVHRS-Q.
In this study we aim to compare the effect of two different ovarian stimulation protocols on embryo quality in a group of women of 39 years or younger, in a prospectively randomized controlled trial. PGS will be performed to assess chromosomal…
Primary objective: To study the influence of repeated oral administration of ketoconazole, a potent CYP3A4 inhibitor, in a therapeutic dose on the plasma pharmacokinetics (PK) of eribulin administered via intravenous (IV) infusion.Secondary…
Aim of this study is to investigate the clinical performance of two restoration techniques, making use of 'direct' and an 'indirect' composite restorations as a minimal invasive intervention in patients with severe tooth wear.…
To identify differences in the mechanisms leading to dysphagia after laparoscopic Toupet and Nissen fundoplication.
Gaining insight in the modulating effects of attention on the processing of short electrocutaneous painful and non-painful stimuli by comparing the patterns in brain activity en subjective measurements during different conditions of attention.…
Primary objective: The main research issue here is whether the intervention with the mirrorfeedback in patients with motor conversion of the arm or hand leads to improvement handgrip strength.Secondary objectives: The secondary research question is…
The primary objective of this study is to assess the objective response rates (ORR) for two starting doses of vandetanib, 150 mg and 300 mg in patients with unresectable locally advanced or metastatic MTC having progressive or symptomatic disease.…
proof of safety of the Style 410 silicon breast implants
What is the effect of the distraction hearing screening strategy compared to the neonatal hearing screening strategy on speech and language development and other developmental parameters in children with permanent childhood hearing impairment (PCHI…
The aim of this pilot implementation is first to make a serious start in Chlamydia screening and secondly to determine feasibility, affectivity and cost-effectivity. The results of this pilot implementation will be leading for the decision about the…
The two main objectives of this experiment is firstly to replicate the finding that repetitive transcranial magnetic stimulation (rTMS) of the inferior frontal cortex (IFC) can interfere with artificial syntactic classification and secondly to…
Primary objectiveTo detect the difference in mean arterial blood pressure between conventional APRV settings and APRV settings based on EIT measurements, in patients with ARDS.Secondary objectivesImproved dorsal ventilation distribution on EIT…
To investigate the efficacy of cognitive behaviour therapy (CBT) on reducing TTF in patients receiving TKIs for CML or GIST.