144 results
To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue.
The purpose of this trial is primarily to assess the efficacy of inhaled mannitol compared with a true placebo in subjects with cystic fibrosis aged 6 to 17 years.We hypothesize that inhaled mannitol will improve the overall health and hygiene of…
Primary Objective:The primary objective in the current trial is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate. The main question we intend to answer in…
We study training effects in patients that receive training in the early CVA-phase (CVA < 6 weeks).Goals:1. Determination of the training effects in the early phase of stroke. 2. Determination of quality of life in trained CVA patients with…
The primary purpose of the study is to investigate whether the new 20 mg capsule of Orfadin® (nitisinone) has a similar bioavailability in the body (gives the same concentration in the blood) as two of the marketed capsules of 10 mg. The secundary…
Evaluation of the effectiveness of a new system HD2/NBI2 to improve the detection of colorectal neoplastic lesions during colonoscopy in comparison to the former generation with currently highest share of the installed base (nonHD-nonNBI system i.e…
measuring the efficicy of the combination of green lipped mussel, curcumin and ribus nigrum (supplement Synofit) on quality of life and pain in patients with osteoarthritis of the knee
The present study aims to determine the bioavailability of hesperidin when micronized and non-micronized, when S-enantiomeric enriched and racemic, and when incorporated in a lozenge compared to a capsule, such that the appropriate dosage form can…
To examine the impact of an exercise bout on the ability to protect endothelial damage in response to ischaemia reperfusion injury in healthy humans. A secondary objective is to explore the potential difference in efficacy to prevent ischaemia…
The objective of the first two cohorts of this study is to explore the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06372865 after a single dose across a wide exposure range up to the maximum tolerated dose or the maximum…
During the last several years, substantial progress has been made regarding the biologic characterization of the acute leukemias. The traditional understanding that myeloid leukemic cells are developmentally similar to their normal hematopoietic…
Primary Objective(s):1. To determine whether aging associated cognitive impairment can be attenuated by roflumilast administration as assessed by cognitive battery tests.Secondary Objective(s):1. To determine whether brain electrical activity (ie,…
To evaluate the effect of parenteral supplementation of fishoil based emulsion (rich in omega-3 fatty acids) compared with a soy bean oil emulsion (rich in omega-6 fatty acids) on the leukocyte functions (amongst others production of TNF-α and other…
To extend our understanding of brain mechanisms involved in intrusive memory degrading by eye movement during recall of traumatic memories in the treatment of PTSD.Brain areas involved in visual imagery are well-documented, and comprise the primary…
The objective of this study is to evaluate the safety and performance of the ROX Coupler in subjects with resistant hypertension.
Primary Objective: Determining the effect of a patellar strap and sports tape on pain and sport participation in subjects with patellar tendinopathy. Secondary Objective(s): Determining the relationship between injury specific, sports related and…
To investigate whether adding a rocker bar (including rounded heel, proximally placed fulcrum and stiffened sole) significantly reduces pain, the range of motion in the ankle and the ankle moments in patients with posttraumatic ankle arthritis.
The main objective is to assess the efficacy of the closed loop system at the home of the patient. Secondary objectives are to assess the safety of the new prototype while the telemonitoring intensity is being reduced during the trial; to…
- To investigate the biochemical response of ITF2984, defined as a reduction in (random) GH < 1.0 mcg/l and/or normalization of IGF-1.- To investigate the biochemical response of ITF2984, defined as a reduction of GH to no more than 2.5 mcg/l…
The current study is aimed to evaluate the procedure of performing a non invasive intervention study by subjects themselves performing the tests at home.