84 results
This study aims at investigating potential relevant QT effects of clazosentan at supra therapeutic doses in healthy male and female subjects using a concentration/response analysis approach in compliance with the ICH E14 guidance [FDA 2017].Primary…
The primary objective is to determine whether a high-fat meal can induce a persistent pro-inflammatory monocyte phenotype, characterized by an increased cytokine production capacity upon ex vivo stimulation. Secondary objectives are metabolic and…
To determine the effect of botulinum toxin type A injections in stroke patients with stiff knee gait.
The objective of the study is to compare the effects of homogenized, unhomogenized and skimmed milk with butter on postprandial metabolism in healthy overweight men.
The primary objective is to investigate if there are differences in the acute postprandial vasodilating effect between different protein sources and if these differences are associated with differences in the responses of vasodilating factors.…
1. to study the effect of spironolacton and triamterene on blood pressure in anuric hemodialysis patients.2. to study the effect of treatment on body weight, serum elektrolytes, 24-hours sodium excretion, plasma aldosterone and renin concentrations…
To compare the blood pressure lowering effect of thiazides against calcium channel blockers in CNI-induced hypertension.
The FLAVO-studie is a scientific study aimed at investgating if (and how) certain pure flavonoids can beneficially influence vascular function.
To study the protective effect of pre-treatment with metformin on flow mediated dilation after 20 minutes ischemia and 20 minutes reperfusion. If metformin treatment indeed limits endothelial IR-injury, a second study will be performed in the same…
The objective of this study is to evaluate the safety and performance of the ROX Coupler in subjects with resistant hypertension.
The aim of this phase I study is to assess the extent of intestinal absorption of rivaroxaban and dabigatran etexilate in adult patients with short bowel syndrome and treated with long-term TPN.
Some studies have reported improved vascular function with the supplementation of L-arginine in participants with CVD. Several clinical studies have also begun the investigation of L-arginine supplementation in participants with PAD. This is…
Primary objective: To compare the anti-hypertensive response to dietary salt restriction with the anti-hypertensive response to the diuretics hydrochlorothiazide/amiloride in patients with CKD stages 3 or 4. Secondary objectives: * To analyze the…
This research will have as aim to look at progression or decrease of vascular calcification in dialysis population with use of different phosphate binders. There is a possibility that differect phosphate binders bind vitamin K in a different way in…
Objective: To test the efficacy and safety of percutaneous renal sympathetic denervation of the native kidneys in the treatment of uncontrolled hypertension in kidney transplant recipients.
To explore the effects of acute fear on the coagulation system while sitting still.
To validate and compare smartphone-connected blood pressure monitors produced by Withings, Qardio and iHealth with the gold standard and a validated automatic blood pressure monitor.
The purpose of this study is to advance our understanding of the behaviour of the coronary microcirculation in the setting of NSTE-ACS, to provide insights into the relationship between Doppler flow velocity and thermodilution-derived coronary…
In this study we aim to elucidate effects of dietary sodium intake on:1. Microcirculation by studying the capillary network during high and low sodium conditions.2. Adaptive and innate immune system by studying circulating T-lymphocyte…
1. To assess the effect of the switch from protease inhibitors to raltegravir on endothelial function. 2. To assess the effect of the intervention mentioned above on markers of endothelial function; immune activation; chronic inflammation; and, on…