373 resultaten
Survival of patients treated with hepatic arterial infusion pump chemotherapy will be superior to that of a historical cohort with similar patient characteristics
We expect that the access-related intervention rate and medical costs will be reduced by 40% when correction of vascular access stenosis is triggered by clinically apparent access dysfunction rather than by asymptomatic flow reduction detected by…
We hypothesize that the T2T strategy is superior compared to the T2S in retaining gout remission and is also more cost-effective.
Spinal anesthesia is a superior anesthesia technique for spinal cord stimulation procedures
The hypothesis is that patients who complete the 30-weeks group schema therapy will benefit from this treatment (i.e., a significant drop in severity in the manifestation of OSPD, as measured with ADP-IV, and secondary outcomes) at Post-Booster and…
We expect to find that e-liquids with nicotine salts taste milder and are easier to inhale than e-liquids with free-base nicotine. More specifically, we hypothesize that e-liquids with nicotine salts, in comparison to free-base e-liquids: 1. are…
Primary • To evaluate the pharmacokinetics of oxybutynin and its main hepatic metabolite N-desethyloxybutynin after pulsed intra-vaginal delivery of a single dose of oxybutynin Secondary • To assess the safety and tolerability of the intra-vaginal…
Onderzoeken of drie weken lang CBD spanningsklachten kan verminderen bij hersentumorpatiënten in de stabiele fase kan verminderen, en zo kwaliteit van leven kan verbeteren. Depressieve klachten, slaap/vermoeidheid en algehele kwaliteit van leven…
Investigate the influence on the hard and soft tissues of immediate placement of a single implant in an extraction socket in the anterior maxilla. Null hypothesis: is that there are no differences in the hard and soft tissues and aesthetic outcome
The intradermal vaccination of a fractional dose of mRNA-1273 LPN vaccine (Moderna) is safe and non-inferior in eliciting neutralizing antibodies against SARS-CoV-2 to the standard dose injected intramuscularly
We hypothesise that HCP provides reproducible and accurate measurements of LV volume changes during different CRT pacing settings which are comparable with invasive conductance catheter measurements.
At two-year follow up, employees of the intervention schools report significantly lower levels of work stress and work stress risks as compared to employees of the control schools
Emerging techniques measuring oxidative APAP metabolites and microRNA-122 (miR-122) could make it possible to detect paracetamol induced liver injury earlier and more precisely than currently used paracetamol plasma concentrations and clinical…
The Trammpolin® medial meniscus prosthesis is intended to restore the function of the natural meniscus to provide unicompartmental pain relief in the meniscus-deficient knee and redistributes the loads transmitted across the knee joint. The ability…
To evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kg
Group Schema Therapy is more effective and more cost-effective than Individual Schema Therapy and than Treatment-as-Usual
Primary hypothesis: An extension of the psychotherapeutic treatment concept by animal-assisted group therapy (plus treatment as usual / TAU) lowers depressive symptomatology, possibly via increases in patients' experience of self-efficacy and…
The number of flares during tapering of biologicals in patient with rheumatoid arthritis can be reduced by using a dynamic flare prediction model
Our hypothesis is that time to complete wound healing in patients with a POWI who receive NPWTi will be shorter than in patients receiving standard wound care (i.e., NPWT and/or conventional wound care). We do not expect that NPWTi pose an extra…
We hypothesize that PARP inhibitors can potentiate radiation-induced tumor cell death in patients treated with PRRT. To determine the maximin tolerated dose (MTD) of this combination, a phase 1 dose-escalation study is needed.