525 resultaten
Emerging techniques measuring oxidative APAP metabolites and microRNA-122 (miR-122) could make it possible to detect paracetamol induced liver injury earlier and more precisely than currently used paracetamol plasma concentrations and clinical…
We hypothesize that the MACE and mortality rates will be very low, due to mild or absent coronary disease on the CCTA and the short follow-up duration.
It is hypothesized that CATs and PROMIS short-forms have higher measurement precision and smaller measurement error (better detectable change) as compared to currently used PROMs.
It is hypothesized that measurement of CO, SV and LVEF with the Lumify/DIA system corresponds with CO, SV and LVEF measurements with conventional non-automated echocardiography.
The clinical efficacy of CFTR modulating drugs is limited, some patients respond, while others do not or have side effects. The inter-individual variability (IIV) in the PK seems large, and therefore we hypothesize that we might be over- or…
To evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kg
We hypothesize that CBFV measurement in the ICA and pACA using Doppler CUS will become a monitoring technique to guide optimizing cerebral perfusion in the perioperative phase. Furthermore, HFR Doppler CUS will provide additional quantitative…
Regarding our main objectives, we hypothesize that patients with a gambling disorder show an increase in dopamine synthesis capacity. Moreover, we hypothesize a positive relationship between individual differences in dopamine synthesis capacity and…
In patients with ANOCA, identification of specific endotypes of vascular dysfunction with intracoronary testing, followed by pharmacological and nonpharmacological interventions aligned to the identified endotype, leads to better control of angina…
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Not applicable
We hypothesize more than 90% of the participants in the in-hospital, standard-of-care follow-up will contact the hospital during the study period and 40-50% of the patients in the patient-led, home-based follow-up will contact the hospital between…
The primary research questions are: 1. To what extent does a 4 week ReHab-TOAT regime lead to improvement of arm function in chronic stroke patients with either a severely or moderately affected arm-hand? 2. To what extent is any improvement of arm…
There are multiple ways of weaning from venovenous ECMO support
We hypothesize that mechanisms of LV remodelling in BD include a larger prolapse volume and underlying genetic substrate, beyond volume overload related to MR, resulting in more severe LV remodelling and dysfunction compared to FED.
Feasibility pilot study towards clinical implementation of a new navigation setup in which we can track the tumor within the rectum during surgery.
It is unclear if DOACs are superior or inferior compared to VKAs in CTEPH/CTED patients regarding (peri-procedural) bleeding and long-term (thrombotic) complications.
We expect to find that e-liquids with nicotine salts taste milder and are easier to inhale than e-liquids with free-base nicotine. More specifically, we hypothesize that e-liquids with nicotine salts, in comparison to free-base e-liquids: 1. are…
Hematopoietic stem cell transplantation (HSCT) is a last-resort, curative therapy for patients suffering from various, otherwise lethal, diseases. Due to improved treatment strategies, the number of HSCT survivors and their life expectancy continue…
Primary • To evaluate the pharmacokinetics of oxybutynin and its main hepatic metabolite N-desethyloxybutynin after pulsed intra-vaginal delivery of a single dose of oxybutynin Secondary • To assess the safety and tolerability of the intra-vaginal…