2398 resultaten
Aspirin use as primary prevention in hospitalized patients recovering from pneumonia can inhibit platelet activity effectively. Also, we wonder if aspirin as secondary prevention in patients with stable cardiovascular disease works as effectively…
Our null hypothesis is that there are no differences in tibiofemoral joint kinematics after ACL reconstruction with LET and the tibiofemoral joint kinematics after ACL reconstruction without LET. Our alternative hypothesis is that ACL reconstruction…
Treatment with dapagliflozin will reduce postprandial hyperlipidemia and thus reduce postprandial leukocyte activation, diminish the generation of postprandial oxidative stress and improve postprandial vascular dysfunction in men with type 2…
Placebo and nocebo effects affect physiological as well as psychological outcomes through expectancies that can be elicited by, for example, conditioning and verbal suggestions. It has been argued that placebo and nocebo effects induced by…
Rationale: Custom-made orthopedic shoes (OS) are frequently prescribed to patients with various pathologies like: diabetes, to prevent originating or recurrence of foot ulcers; rheumatoid disorders or degenerative foot disorders, to reduce pain and…
Daily protein supplementation during long-term endurance exercise training augments the physiological adaptations to endurance exercise training.
A relationship can be identified between HbA1c levels and self-management and quality of life. It appears better self-management skills result in a larger improvement of HbA1c levels, and the other way around, getting control over HbA1c levels is a…
The plasma concentrations of inflammatory mediators of AP subjects are similar to those of non-AP controls and elimination of the endodontic infection does not result in changes of the systemic inflammation. Finally ) to investigate the microbiome…
Hypothesis 1: Participants in both conditions (experimental and placebo) will show a reduction in gamble problem severity immediately post-intervention and at 3-and 6-month follow-ups. However, participants in the experimental condition will show a…
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
A combination therapy (MDT and TESIs) is effective and cost-effective compared to usual care among herniated nucleus pulpos patients with an indication for a lumbar herniated disc surgery
A strategy aimed to switch from INR-guided VKA therapy to a NOAC-based treatment strategy is superior to continuation of INR-guided VKA therapy with regard to the occurrence of major or clinically relevant non-major bleeding complications in frail…
Trends in and variability of vital signs reveal hidden information about the state and deterioration of the patient compared to absolute values of vital signs.
We hypothesize that the ingestion of an additional amount of dietary protein (2 x 15g per day) will increase muscle strength and physical performance in physically active elderly (≥ 65 yrs). Moreover, we hypothesize that the ingestion of additional…
• To evaluate the safety and tolerability of four different single oral doses of LII-291 in healthy subjects. • To characterize the plasma pharmacokinetics (PK) of LTI-291 following single oral dosing in healthy subjects. • To evaluate the…
Infant formulae with higher levels of milk fat result in improved fatty acids absorption as compared to standard formula.
Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
A disease control of 60% is expected and will be clinically relevant with a lower reference bound of 45%.
The aim of this large multicentre prospective cohort study is to compare rib fixation with nonoperative treatment of a flail chest and multiple rib fractures by evaluating treatment effects in ‘real-world’ patients treated in different level 1…
a) What are the effects of the AddictionBeater on alcohol-related approach bias and implicit associations? Participants completing the AddictionBeater and the non-gamified real CBM training would show a greater reduction in alcohol-related approach…