2168 resultaten
A mathematically correct PK-PD model will be developed that describes the depressant effect of propofol on breathing with and without a background of remifentanil.
We hypothesize that, with increased arm abduction moment loading with a constant exerted abduction force, primary arm moment generators (deltoid muscle) will have a greater increase in activation (EMG) as compared to primary arm/glenohumeral…
The aim of this study is to determine the (cost)effectiveness of a home-based functional training programme as compared to regular physical therapy with regard to the ability to live independently and participation of frail elderly of 75 years and…
Assessment of feasibility of neoadjuvant chemotherapy consisting of docetaxel, cisplatin and capecitabine in resectable localized gastric cancer (stage Ib-IVa) and the introduction of the D1extra-lymphadenectomy as the standardized surgical…
The main objective of the present study is to evaluate (cost)effectiveness of Dementia Care Mapping (DCM)intervention in nursing home dementia care by performing a large RCT study.
We hypothesize that the Ketogenic diet will be cost-effective compared to usual care.
The first aim of this study is to evaluate the development of motor skills (goal directed arm movements) in children with a visual impairment compared to normally sighted peers. Our hypothesis is that children with a visual impairment have poorer…
Healthcare professionals need to encourage physical activity according to the guideline for cardiovascular risk management. Patients with cardiovascular risk factors (abdominal obesity, high blood pressure, low HDL cholesterol, elevated…
1. SMOFlipid® decreases peripheral insulin sensitivity to a lesser extent compared to the other lipid emulsions, Intralipid® and Clinoleic®, due to the lower n6/n3 ratio and the higher MCT concentration in the SMOFlipid emulsion; 2. SMOFlipid®,…
To determine the correlation between enhancement curves at DCE-MRI with T1-map and the level of histopathological activity.
1. The point of the skin with best possible transcutaneous nerve stimulation correlates with the point of the skin most superficial to the nerves stimulated within a range of 3 mm; 2. Ultrasound will reveal a significant number of sensitive…
Is there a difference in the recurrence rate if you treat a cyst or abscess of the bartholin gland with a marsupialization or placement of a word catheter.
We hypothesize that subjects suffering from hypothalamic dysfunction may have a hyposerotonergic neurotransmission. Therefore we will investigate if there are differences in specific hypothalamic-to-nonspecific [123I]FP-CIT binding ratios using…
The objective of the study is to identify factors associated with anterior knee pain after primary total knee replacement.
The aim of this study is to investigate whether the optical tissue stylet technology can discriminate tissues that are relevant for interventional pain procedures.
We hypothesize that a treatment algorithm that is based on a simple validated measure of health status (CCQ) improves quality of life (as measured on a separate scale) and other classical COPD outcome measurement parameters such as exacerbation…
The primary research hypotheses are: 1. Patients who follow the Onco-Move program will achieve better physical fitness levels, as assessed by objective performance tests, and will report less fatigue than patients in the usual care control group; 2…
Public health authorities have recognized lack of hand hygiene (HH) as one of the important causes of preventable mortality and morbidity at population level. Both at national (UK, USA, Dutch VMS) and international levels (WHO) poor HH has been…
The purpose of this study is to demonstrate the added value of using 'LMA-S in the ambulance with CPR in the Netherlands indigent patients. The hypothesis is that the value of using the LMA-S is located in the safety and speed of placing the…
There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…