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Closing wedge osteotomy with plate fixation only will result in earlier mobilisation and better one year results considering pain and function then staple and cast fixation.
We hypothesize that in preterm infants with a gestational age below 34 weeks a low threshold intervention (progressive PHVD with a ventricular enlargement above the 97th centile for gestational age according to Levene and a diagonal width…
A self-management programme guided by doctors and a specialist asthma nurse through information and communication technology will improve asthma related quality of life in a cost-effective way.
Efficacy of minimal intervention strategy (isolated training of the lumbar extensors) with the use of a control group receiving usual care.
Efficacy of inhaled DNase in children with an airway malacia and a lowerrespiratory tract infection.
We hypothesize that DNase improves mucociliary clearance and mucus retention in patients with (trachea)bronchomalacia during a lower respiratory tract infection, resulting in a faster resolution of symptoms and shorter duration of a lower…
The overall survival in the arm treated without chemotherapy (TNM-stage II or III tumours) is expected to be approximately 60%. Assuming an improvement in overall survival from 60% to 70% in the arm treated with chemotherapy (TNM-stage II or III…
Surgery is the standard therapy for esophageal cancer. However, 30% of the resections are irradical. It is thought that preceding chemoradiotherapy will improve the surgery results.
Research questions: 1. Is a multidisciplinary intervention programme more effective than usual care in preventing new falls and functional decline among community-dwelling elderly people who visit a GP cooperative and/or A&E department at a…
Early surgical treatment (exploration followed by resection (pancreatoduodenectomy or bypass) in patients with obstructive jaundice due to a pancreatic head tumor is equivalent in terms of severe complications of treatment compared with patients who…
In patients with intraventricular haemorrhage caused by extension from an intracerebral haemorrhage, ventricular drainage combined with intraventricular thrombolysis improves three month outcome when compared to standard treatment.
Chemoradiation therapy for irresectable T4 esophageal tumor improves response rate and survival compared to radiotherapy alone.
There is no hypothesis in this implementation study, that is designed to record facilitating and inhibiting factors when an accepted and well functioning care programme is introduced in four early adopter hospitals.
1. In patients with non-specific low back pain, 10 ml lidocaine 2% reduce the pain more then 2 cm at the BOX-score compare to the placebo group; 2. In patients with non-specific low back pain, 9 ml lidocaine 2% with 1 ml corticosteroid (40 mg…
On the assumption that N-acetylcysteine might prevent acute contrast induced nephropathy in critically ill patients, we study the effects of prophylactic intravenous administration of N-acetylcysteine in critically ill patients with renal…
A sustained inflation with a mechanical device and early nasal continuous positive airway pressure is a more effective management strategy for RDS in preterm infants than conventional intervention with a self-inflating mask and bag and reduces the…
Unlike other potential sepsis treatments, Alkaline Phosphatase has been shown to act at the front end of the inflammatory cascade. By doing so, it eliminates the root cause of the SIRS, and prevents the progression into sepsis and septic shock.
A self help brochure will help people decrease their excessive worrying. and telephonic support will increase the effect.
Multi-centre open label clinical trial.
Inhalation of rhDNase before sleep increases the expiratory flow at 25% of the actual forced vital capacity (MEF25) compared to inhalation of rhDNase in the morning.
Patients who are in 1st CR after autologous transplantation, may be randomized between no further treatment (arm A) and maintenance chemotherapy (arm B). The hypothesis to be tested is that maintenance therapy will prolong disease free survival,…