31 resultaten
The proposed study seeks to investigate the effectiveness of a booklet self-help program in the treatment of depressive symptoms among people living with HIV. We will compare the booklet self-help program with an attention only control condition. In…
Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…
Since progression from NAFLD to NASH is associated with significantly increased risk of morbidity and mortality, there is a clinical imperative to identify the NAFLD patients that rapidly progress to NASH from those who will remain in the NAFLD…
The main objective of this study is to compare upper extremity dysfunction (UED) following slender TRPCI using small bore catheters (5F) compared to standard PCI using regular size guiding catheters (6F) and conventional stent techniques at two…
We hypothesize that UDCA on top of ezetimibe leads to an increased cholesterol excretion via the feces by stimulating ABCG5/8 and preventing absorption of cholesterol due to blocking NPC1L1 and therefore promoting elimination of cholesterol from the…
Tacrolimus (FK506) is the main immunosuppressant that is prescribed after kidney transplantation. One of the disadvantages of Tacrolimus is the small therapeutic window. In transplantation patients therapeutic drug monitoring is routinely performed…
We hypothesize that ID is an important factor in the limitation of exercise capacity in HFpEF. Systemic low-grade inflammation does not only lead to microvascular dysfunction but also to iron deficiency. Iron deficiency has a direct effect on the…
the present study investigates whether a small-scale stay in an enriched green environment in a care center is related to a slower progression of cognitive functions, better mood, less behavioral problems, and a higher quality than if standard care…
The primary hypothesis is that a novel clinical decision rule for pulmonary embolism (the YEARS strategy) is at least as safe as previous studies, yet with an increased proportion of patients safely not referred for CTPA, thus fewer false-positive D…
We hypothesize that there is no difference in the number of patients experiencing partial flap loss at six months post operative.
It is hypothesized that FAME has a positive impact on family functioning and prevents further development of parental symptoms of anxiety and depression.
The actual ERAS statement regarding intra- and postoperative analgesia recommends to not use thoracic epidural catheters in laparoscopic surgery anymore as a gold standard. This cohort study will investigate an alternative possibility of pain…
Stabilisation of preterm infants performing physioloigcal based cord clamping using the Concord is at least as effective as stabilisation according to the standard approach using the standard resusciation table.
To compare a ventilation strategy that uses conservative targets (PaO2 55-80 mmHg (7.3-10.7 kPa)) with one that uses conventional oxygenation targets (PaO2 110-150 mmHg (14.7-20 kPa)) for arterial oxygenation. Primary endpoint is all-cause mortality…
LRRK2 activity is linked to central mechanisms of Parkinson’s disease pathology through its role in lysosomal function, and LRRK2 kinase inhibitors, such as DNL201 (IND Number: 133665) represent a new class of therapeutics with potential to address…
Obesity is significantly associated with Atrial Fibrillation (AF), and, interestingly, if obese patients loose weight, AF dissapears in 50% of the cohort. On the other hand, adipose tissue (AT) functioning alters up weightchange. Therefore we…
Ex vivo organoid response correlates to in vivo response to standard first line treatment in mCRC patients on a metastasis level, therefore organoids can be used to predict response to therapy and select patients for a specific treatment.
1. An early screening at 1y of corrected age will identify preterm children with an increased risk of developing visual processing dysfunctions 2. Early visual rehabilitation from 1y of corrected age will benefit the visual and neurocognitive…
In this study, the primary objective is to compare MTX-PGn levels in PBMCs of RA patients with levels in RBCs and serum and to determine the correlations with clinical response. The secondary objective is to investigate route of administration-…