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We hypothesize that PARP inhibitors can potentiate radiation-induced tumor cell death in patients treated with PRRT. To determine the maximin tolerated dose (MTD) of this combination, a phase 1 dose-escalation study is needed.
• There is no difference in number of bonding failures between the direct and indirect bracket bonding methods • Patients favour indirect bracket bonding over direct bracket bonding • Brackets bonded with the indirect bracket bonding will have less…
Short hydration during cisplatin chemo radiation is significantly more effective than long hydration in preventing acute kidney injury
Two doses of the Coronavirus virus-like particle subunit vaccine ABNCoV2 in SARS-CoV-2-naïve healthy adults is safe and well tolerated.
Postoperative pain management by using either regional continuous PVB or single shot ICNB is non-inferior to TEA regarding pain in patients undergoing thoracoscopic anatomical lung resection. Regarding QoR after surgery the unilateral regional…
the quality of consultation can be improved
Simular outcomes in patients with 4 implants compared with patients with 6 implants with respects to peri-implant bone level stability
- Six weeks of ESM combined with personalized feedback sessions, compared with treatment as usual (TAU), leads to a stronger reduction in fatigue symptoms (primary outcome clinical effectiveness). - This intervention also leads to improvements in…
Determination of preoperative cell-free DNA and circulating tumor cells alone or in combination with each other in peripheral blood of patients with colorectal liver metastases can discriminate between patients who have a recurrence of metastatic…
The hypothesis is that a single course of 12Gy preoperative radiotherapy may lead to sufficient fibrosis in a small (4cm) targeted area of pancreatic tissue where the anastomosis with either the jejunum will be created, thereby reducing the risk of…
patients with a history of drug allergies carry more HLA risk alleles than patients without drug allergies.
Diaphragm thickness is constant throughout the zone of apposition in craniotomy-caudal direction
We hypothesize that the MACE and mortality rates will be very low, due to mild or absent coronary disease on the CCTA and the short follow-up duration.
It is hypothesized that CATs and PROMIS short-forms have higher measurement precision and smaller measurement error (better detectable change) as compared to currently used PROMs.
The Trammpolin® medial meniscus prosthesis is intended to restore the function of the natural meniscus to provide unicompartmental pain relief in the meniscus-deficient knee and redistributes the loads transmitted across the knee joint. The ability…
The aim of the present study is: can a single case observation of two distinct phases during systole (laminar and turbulent) be confirmed in other patients with aorta stenosis?
1/2. Postoperative infections are a risk factor that negatively interferes with physical recovery 1 year after cardiac surgery. It is expected that propensity scoring techniques will provide a more accurate (“unbiased”) estimate of the effect of the…
The clinical efficacy of CFTR modulating drugs is limited, some patients respond, while others do not or have side effects. The inter-individual variability (IIV) in the PK seems large, and therefore we hypothesize that we might be over- or…
To evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kg
We hypothesize that the combination of LFPs (recorded with implanted DBS electrodes) and resting state fMRI and 64-channel EEG can provide insight in the thalamocortical coupling and other brain circuits involved in the disturbed brain dynamics in…