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We recently found that memories can be weakened by applying electroconvulsive therapy (ECT) shortly after reactivation of a memory (Kroes et al., 2014). This suggests that reactivation of negative schemas just prior to ECT may also weaken those…
Our primary outcome is change in suicide ideation in patients. We hypothesise that, as a result of the improved skills and confidence of healthcare professionals in the experimental condition due to the intervention, suicidal patients are better…
The objective of the study is to investigate the effect of virtual reality training, given between 2 weeks and 6 months after stroke, on participation and subjective physical functioning in independently living patients.
We hypothesise that the Taperloc BoneMaster coated stem is equal or better than conventional porous coated or cemented stem focussing on implant ingrowth and bone remodelling.
Perioperative maintenance of cardiac output and pulse pressure variation result in an overall reduction in postoperative complications when compared to arterial blood pressure-guided perioperative hemodynamics in patients undergoing elective…
We aim to study the SARS-CoV2 infection/disease course via dissection of the cellular immune response in blood, with special attention to antigen-specific T-cells and B-cells and antibody formation against viral proteins, particularly blocking (=…
Spinal anesthesia induces several alterations in normal brain processes. Firstly, loss of afferent information increases pain sensitivity. In our previous study on the effects of spinal anesthesia (P11.221) we showed that subjects felt more pain…
1. Blood-brain barrier permeability is quantitively increased in patients with cerebral small vessel disease compared to healthy controls; 2. Blood-brain barrier permeability is associated with cognitive function in patients with cerebral small…
The aim of this study is to investigate the effect of the implementation strategy on level of implementation of palliative care and the effects on patient, informal caregiver and professional outcomes. It is hypothesized that implementation of…
We hypothesize that in this short term study the testproducts with added fibre will increase satiety, slower gastric emptying, will give a later blood glucose peak and that it will decrease energy intake when compared to the controlproduct.
The main hypothesis is that PM+/care-as-usual (CAU) will decrease psychological distress as compared to CAU alone.
The hypothesis is that the slope of the curve will predict patient outcomes
Is there a clinical relevant difference in change in International Knee Documentation Committee” (IKDC) questionnaire over a period of 24 months of an early surgical intervention versus a more conservative management of patients with a complete ACL…
We hypothesize that acetaminophen and nimodipine have a positive influence on postictal phenomena after ECT induced seizures and this is mediated by a reduction of postictal cerebral hypoperfusion.
1. In normoglycaemic critically ill children exogenous glucose administration diminishes endogenous glucose production; 2. Elevated blood glucose levels in critically ill children are caused by the sum of an increased endogenous glucose production…
One out of three breast cancer survivors suffer from severe fatigue after curative cancer treatment. Cognitive behavioural therapy (CBT) for severely fatigued cancer survivors is an effective intervention. However, the intervention is intensive and…
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We hypothesize that exogenous, enterally provided glutamine contributes substantially to the de novo synthesis of arginine in surgical patients. We hypothesize that aortic replacement surgery contributes to an alteration in arginine metabolism by…
Caregivers' sense of competence will improve significantly more in participants of the intervention group compared to the participants in the usual care group.
This study aims to answer two research questions: 1. Does web-based monthly monitoring using the Asthma Control Test (ACT) improve asthma control? Is this strategy cost-effective? 2. Does asthma management guided by the fraction of nitric oxide in…