5369 resultaten
Wij stellen de hypothese dat een ontstekingsremmend voedingspatroon (AIDP) een gunstig effect heeft op het darmmicrobioom (diversiteit en permeabiliteit), waardoor het globaal functioneren (gemeten met Outcome Questionnaire 45, OQ-45) en de…
We hypothesize that an evidence based diagnostic algorithm, using fewer and preferably the least invasive diagnostic modalities can approach the accuracy of the complete panel of diagnostic tests.
It is the aim of this study to establish an integrated risk profile including clinical risk factors, AF recurrence patterns, anatomical and electrophysiological characteristics, circulating biomarkers and individual genetic background, to predict…
Nonsimultaneous current steered pulse trains will lead to a single pitch percept whilst reducing the amount of current in comparison to conventional monopolar stimulation
Background: Multiproblem young adults (between ages 18 and 27), characterized by a variety of severe psychosocial problems, comprise a societal challenge with high priority on the political agenda, both nationally and internationally. However, so…
We hypothesize that PARP inhibitors can potentiate radiation-induced tumor cell death in patients treated with PRRT. To determine the maximin tolerated dose (MTD) of this combination, a phase 1 dose-escalation study is needed.
DBS leads to a symptom reduction in patients with OCD
It is hypothesised that compared to waiting list control condition, participants in the intervention improve their diet and physical activity on the short (6 months after baseline) and long-term (12 months after baseline; when the participant…
We hypothesize that by using different imaging techniques, we can give a good characterization of the bone marrow microenvironment in advanced-stage myelofibrosis, before and during treatment with ruxolitinib.
A safe RP2D of Vyxeos®/CPX-351 in combination with clofarabine can be identified in this phase 1b study.
Benign liver tumors and cysts carry a significant burden on the quality of life in some cases. Apart from impairing symptoms, psychological burden might provide sufficient ground for surgical intervention. There is a variable approach to them…
Een klinisch behandelprogramma met een opnameduur van acht weken gevolgd door een intensief vervolgprogramma voor kinderen (8-19 jr.) met ernstige obesitas is kosten effectiever dan een klinische interventie met een opnameduur van zes maanden en…
It is expected that HFNC therapy will speed up the recovery of an exercise induced lung function decline. We speculate that the time to recovery to their normal lung function will be halved.
Our hypothesis is that adolescents that have been educated on an 'enjoy being fit' elementary school exhibit healthier scores than adolescents that have been educated on a regular Elementary school on the set of outcome variables. However…
The aims of the study are: To investigate the short-term effectiveness of antecedent and consequent behavioral teacher training techniques for teachers of children attending regular primary school (class 3 to 8, six to thirteen years old) with (…
Our hypothesis is that routine application of elastic stockings after varicose vein surgery is not beneficial with regard to pain- and physical functioning scores, complications, edema formation, time before returning to work and analgesics…
We hypothesize that RPCA is as effective in reducing pain relief scores as EA, with lower costs and easier achievement of 24 hours availability of pain relief for low risk women in labor.
Parenting is essential for the upbringing of social, mentally and physically healthy children. Parenting interventions can support parents in this process. In general, parent training programs have a positive influence on various outcomes related to…
Increased cardiac sympathetic activity is highly prevalent among patienst with chronic heart failure. The increased cardiac sympathetic activity as assessed with 123I-metaiodobenzylguanidine (MIBG) is a usefull tool to discriminate responders (i.e.…
Early treatment of a clinical varicocele in subfertile men results in more spontaneaous pregnancies as compared to no treatment.