495 resultaten
Lung transplantation patients are immunocompromised due to antirejection therapy. The effectivity of the COVID-19 vaccination in this high-risk patient group is completely unknown.
The primary hypothesis is that local antibiotics are a safe treatment option in the prevention and treatment of fracture-related infections, achieving higher local concentrations without the potential adverse events associated with systemic…
It is unclear if DOACs are superior or inferior compared to VKAs in CTEPH/CTED patients regarding (peri-procedural) bleeding and long-term (thrombotic) complications.
helicopter transport can be done safe without changes in vital signs
The hypothesis is that methylation marker panel, potentially combined with additional biomarkers, can predict (non-)regression of HGAIN, thus determining the need of immediate treatment versus active surveillance, and the safety of withholding…
The main endpoint will be successful sampling and storage of testicular tissue (that is 75% of the samples to be stored for future stem cell preservation will have germ cells). This can be identified based on histological analyses (immuno-),…
none applicable
Participant demographics affect the health state. TPO-RA treatment affects the severity of symptoms, overall health condition, health state, overall satisfaction with therapy and reasons for discontinuation. TPO-RA treatment affects direct…
Primary - To evaluate disease-related characteristics and biomarkers in patients with mycosis fungoides compared to healthy volunteers; Secondary - To evaluate intra- and inter-patient variability of the selected biomarkers; - To evaluate biomarkers…
We expect an increase in the number of hospitals that have implemented and use a cognitive aid in the OR compared to the number of hospitals in 2018
The main objectives of this study are: • To gain insight into the effectiveness of the Healthy Working Approach on need for recovery in elderly care workers over one year. • To gain insight into the process of implementing the Healthy Working…
The lifestyle program will improve the quality of life and lifestyle behavior, and will decrease the healthcare utlization, comorbidity and cancer recurrence rates.
Gastric fluid volumes in patients with a 6-4-0 pre-operative fasting regime are comparable to patients with a 6-4-2 pre-operative fasting regime
We hypothesise that standard anaesthetic management guided by mitoPO2 monitoring to optimise tissue oxygenation, using conventional measures, results in higher tPO2 during surgery and, therefore, a higher mean mitoPO2 over time.
The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…
Exploration
Alveolar macrophages do not depend on glucose metabolism during infection, but on another metabolic source.
Because of the qualitative nature of this study, no hypothesis is applicable
The purpose of this study is to investigate how safe the new compound KCP506 is and how well it is tolerated when it is administered to healthy volunteers. It will also be investigated how quickly and to what extent KCP506 is absorbed and eliminated…
We hypothesize that treatment with Sustained Release Calcium Butyrate (SRCaBu) will ameliorate: 1) the intestinal microbiome, intestinal barrier function and immune tolerance: 2) lower systemic inflammation of OA of the hand.