398 resultaten
1. Assessment of safety of seasonal and pandemic inactivated whole virion influenza vaccines; 2. Assessment of immunogenicity of the whole virion vaccines; 3. Comparison of the safety profile of the whole virion vaccines with a split virion vaccine.
Remote ischemic preconditioning (RIPC) has been shown to attenuate myocardial damage in cardiac surgery. We hypthesize that RIPC induced cardioprotection is associated with an increased amount of mitochondrial hexokinase.
The aims of the study are: 1. To compare the effectiveness of Cognitive Behavioral Therapy (CBT) for anxiety disorders between children with ASD and children without ASD; 2. To compare the (cost-) effectiveness of CBT to Treatment As Usual (TAU) for…
1. The first hypothesis is that treatment of panic disorders with or without agoraphobia with EMDR as well as with CBT will lead to symptom reduction. This symptom reduction is expected to be larger in the EMDR treatment group than in the CBT…
Primary Objective: Our primary objective is to compare the midterm clinical and radiographic results (6 to 8 years) of CWO versus OWO with a locked plate fixation in the management of patients with medial knee OA and a varus leg alignment with a…
We aim to use Epstein-Barr Virus (EBV) within nasopharyngeal carcinoma (NPC) tumour cells as therapeutic target. In these cells EBV “hides” in a latent state due to methylation of the viral promoters, expressing only few non-immunogenic viral…
Laparoscopic appendectomy ameliorates the disease course and prevents colectomies, corticosteroid use and immunomodulation in newly diagnosed ulcerative colitis.
Increasing kidney function by kidney transplantation might improve the circadian rhythms of melatonin concentration, sleep and 24-hour blood pressure profile.
Intravenously administered rhAPC has protective effects on HDM-LPS induced allergic lung inflammation.
In the present proposal we aim to study whether the intrauterine application of hyaloronic acid (Hyalobarrier ® Gel Endo) immediately after curettage, in patients with a recurrent curettage reduces the incidence and severity (ESGE score/…
Incorporation of vitamin E to a polyethylene acetabular cup gives less wear at 10 years compared to cross-linked polyethylene without vitamin E.
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The addition of a Functional Capacity Evaluation to a cognitive behavioral intervention will improve work ability, quality of life and self efficacy.
1. Muscle ultrasound is capable to detect dermatomyositis and polymyositis in suspected patients; 2. Muscle ultrasound is capable to detect improvement of structural muscle changes induced by treatment; 3. Muscle ultrasound is capable to detect…
We hypothesize that exercise training will: 1. Improve aerobic fitness; 2. Will not result in adverse remodeling and/or decline of ejection fraction; 3. Will increase daily activity levels; 4. Will improve health related quality of life and…
The primary goal of this study is to determine whether it is possible to discontinue treatment with TNF blocking therapy in patients suffering from Rheumatoid Arthritis when the patient has had stable low disease activity.
Our primary outcome is change in suicide ideation in patients. We hypothesise that, as a result of the improved skills and confidence of healthcare professionals in the experimental condition due to the intervention, suicidal patients are better…
Most treatment comparisons include high doses of gonadotropins and only vary in their means of ovarian suppression ie GnRH agonist versus antagonist or no downregulation at all. High doses of gonadotropins did not result in higher pregnancy rates…
1. All obese patients have low-grade systemic inflammation characterized by IL-6, TNF-alfa, leptin and adiponectin. Patients with obesity and asthma have higher expression of these mediators and neutrophils in bronchial mucosa than obese patients…
Intensive pharmacovigilance in high-risk patients, much less intensive pharmacovigilance in low-risk patients and an education program for prescribers will lead to a reduction of medication related events (death, disability, increased hospital stay…