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Non-inferiority (defined as < 12.5% increase) of pooled buffy coat-derived PR platelet concentrates (PR-plasma-PCs) compared to plasma (plasma-PCs) in terms of clinical efficacy determined by WHO grade ≥ 2 bleeding complications.
Background: Multiproblem young adults (between ages 18 and 27), characterized by a variety of severe psychosocial problems, comprise a societal challenge with high priority on the political agenda, both nationally and internationally. However, so…
The null hypothesis of the primary outcome measure is that there will be no significant differences in DASH scores 6 months after surgery between patients who underwent plate fixation or intramedullary fixation with a TEN. The alternate hypothesis…
Dental caries lesions (with ICDAS Codes 3 and 4) can be treated by sealing, offering a less invasive and less costly treatment option with the same results as preparation and restoration of the carious lesions.
1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…
1. The primary research inquiry being raised concerns anaesthesia related causes: Is it possible that adapting an amount of Sevoflurane, from 1 MAC (minimum alveolar concentration) (2,5 vol%) to ½ MAC (1,25 vol%) in an MRI scan can reduce the…
The primary objective is to demonstrate the non-inferiority of bevacizumab to ranibizumab in the treatment of patients with subfoveal CNV secondary to AMD as determined by the change in best-corrected visual acuity in the study eye from baseline to…
• There is no difference in number of bonding failures between the direct and indirect bracket bonding methods • Patients favour indirect bracket bonding over direct bracket bonding • Brackets bonded with the indirect bracket bonding will have less…
Short hydration during cisplatin chemo radiation is significantly more effective than long hydration in preventing acute kidney injury
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the e-support program for parents of children with a chronic kidney disease; 2. to identify outcome measures most likely to capture potential patient…
The study of determinants of cardiovascular disease (CVD) is important because it provides insight in risks and opportunities to reduce the burden of CVD. A major gap in our current knowledge about CVD lies in the way we measure these determinants,…
The guided internet-based behavioral activation intervention is expected to show favorable effects in comparison to online-delivered minimal psychoeducation without support in participants with depressive disorders, as shown by the results on…
The overall aim of this RCT is to examine whether an individual music intervention can improve the challenging behavior, quality of life, emotional wellbeing and EF of adults with a mild to moderate ID.
Radiofrequency ablation (RFA) will lead to permanent and complete eradication of Barrett's epithelium. This will prevent development of high grade intraepithelial neoplasia (HGIN) or early carcinoma and may eliminate the need for endoscopic…
An activity stimulation program improves mobility performance and fitness in children with cerebral palsy.
H0= Postprandial muscle protein synthesis rates do not differ between the 2 intervention groups (P>0.05) H1= Postprandial muscle protein synthesis rates differ between the 2 intervention groups (P<0.05)
It is hypothesized that both positive verbal suggestions regarding an inert substance and a positive imagery exercise result in a lower sensitivity to physical sensations (pain, itch, and fatigue) than neutral verbal suggestions and/or neutral…
Changing the context in which individuals make lifestyle choices has a sustained impact on the dietary intake and cardiometabolic health.
The is that receiving Health Potential, in combination with a current health status check, the Stofberg Health Check, will lead to greater improvements in behaviour change compared to receiving the Stofberg Health Check only.
1. The intervention is effective in reducing eating disorder symptoms; 2. There is an incremental effect of intensive/frequent support from a coach in terms of reducing ED symptoms.