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Due to the lack of information about DON absorption and excretion, the aims of this study are the description of the DON and metabolites excretions patterns and know the absorption and excretion rates of it. Moreover, the results can be useful to…
Treatment with dapagliflozin will reduce postprandial hyperlipidemia and thus reduce postprandial leukocyte activation, diminish the generation of postprandial oxidative stress and improve postprandial vascular dysfunction in men with type 2…
Daily protein supplementation during long-term endurance exercise training augments the physiological adaptations to endurance exercise training.
Hypothesis 1: Participants in both conditions (experimental and placebo) will show a reduction in gamble problem severity immediately post-intervention and at 3-and 6-month follow-ups. However, participants in the experimental condition will show a…
We hypothesize that the ingestion of an additional amount of dietary protein (2 x 15g per day) will increase muscle strength and physical performance in physically active elderly (≥ 65 yrs). Moreover, we hypothesize that the ingestion of additional…
• To evaluate the safety and tolerability of four different single oral doses of LII-291 in healthy subjects. • To characterize the plasma pharmacokinetics (PK) of LTI-291 following single oral dosing in healthy subjects. • To evaluate the…
Infant formulae with higher levels of milk fat result in improved fatty acids absorption as compared to standard formula.
In EPF, the sequential combination of mifepristone with misoprostol is superior to the use of misoprostol alone in terms of complete evacuation of products of conception, patient satisfaction, complications, side effects and costs.
During treatment with dexamethasone, the deprived mineralocorticoid receptor may cause serious cerebral side effects. Hence, it is feasible that these side effects on mood, behaviour and cognition could be prevented, by an intervention with a…
Oral fosfomycin-trometamol is non-inferior to oral ciprofloxacin with regard to clinical cure rate in the step-down treatment of E.coli AF-UTI in women.
We hypothesize that both nitrate and sucrose will reduce GI damage and improve GI blood flow during high-intensity exercise compared with placebo.
The main objective is to understand the effects of the addition of L-arabinose to a drink that has disturbing factors like fat and starch on the reducing glycemic and insulinemic responses of L-arabinose after ingestion of a combined L-arabinose-…
Primary Objective: Investigate the effect of modafinil (200 mg) and caffeine (300 mg) on vigilance in low, medium and high caffeine consumers during the circadian trough in order to determine: - To what extend vigilance during the circadian trough…
Influenza is a major cause of morbidity and mortality, especially among elderly individuals. Due to ethical constraints, no randomized controlled trials (RCT) are conducted evaluating serious outcomes such as mortality. Therefore, evidence base…
Cabozantinib improves overall survival in patients with hepatocellular carcinoma compared with placebo
In this randomised, double-blind, placebo-controlled single centre study we propose to study the effect of duodenal infusion of single E. hallii treatment (administered via duodenal tube) on small intestinal gene expression, bacterial composition…
• To evaluate the safety and tolerability of four oral dose levels of LTI-291 following multiple administrations in healthy middle-aged to elderly subjects. • To characterize the plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of LTI-291…
H0: The effect of product A is equal to the effect of product B with respect to change from baseline after 8 weeks of study product intake in IL-10 production [pg/mL] AND in Foxp3 expressing cells. H1: The effect of product A is unequal to the…
The primary hypothesis is that attentional bias modification (ABM) training towards and away from pictorial itch stimuli results in altered attention for pictorial itch stimuli. Secondarily, it will be explored whether attentional bias modification…
Treatment with alirocumab will reduce postprandial hyperlipidemia and thus reduce postprandial leukocyte activation, diminish the generation of postprandial oxidative stress and improve postprandial vascular dysfunction in men with type 2 diabetes…