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What is the influence of protective gear on the performance of basic life support (BLS) by KNRM lifeboat crewmembers during a manikin simulation training
1. Volume intervention by a diuretic and moderate sodium diet potentiates the antiproteinuric effects of aliskiren in patients with residual albuminuria during conventional RAAS-blockade; 2. Aliskiren neutralizes the reactive rise in plasma renin…
Suppression of SWS, without changing total sleep time, may affect total energy expenditure (TEE), activity induced energy expenditure (AEE), non-exercise activity thermogenesis (NEAT), endocrinological parameters and energy intake.
Primary objective: Does a 30-minute episode of helium breathing in humans decrease the amount of pro-inflammatory cytokines and chemokines produced in whole blood after immunostimulation ex vivo?
Reversibility of oral direct factor Xa inhibitors rivaroxaban and apixaban will be the same when a lower dosage of prothrombin complex concentrate (Cofact®) is used. Infusion with doses of 37.5 or 25 units/kg of PCC would be able to reverse the…
The PSQI score is significant lower in the intervention group as compared to the placebo group after 3 weeks of oral intake of the test product.
1. DBD adolescents will show diminished fear conditioning as compared to HCs in the basic condition, and this phenomenon is associated with altered function, connectivity and structure of brain areas known to be involved in fear conditioning. 2. DBD…
Subjects in the PCD-04 arm will show less anthracyclin-induced cardiotoxicty then subjects in the placebo arm.
This study was therefore designed to determine whether cinnamon lower postprandial blood glucose, and insulin levels in subjects with type 2 diabetes or impaired glucose tolerance.
The hypothesis is that testosterone supplementation improves functional mobility, quality of life, body composition, cognitive function, aortic stiffness and cardiovascular risk factors, and bone mineral density compared to placebo.
Supplementation with omega-3 LCPUFA from krill oil in healthy adolescents will result in: - improvement of the omega-3 index - improved cognitive performance - improved mental well-being - better academic achievement
single denosumab injection has a beneficial effect on shortening time in contact cast and foot form preservation in DM subjects with an acute charcot foot
We hypothesize that probiotics with vitamin K2 producing properties can improve vitamin K status.
Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP
Primary objective of this randomized controlled trial is to assess whether combining IVIg and methylprednisolone leads to more frequent long-term remission in CIDP compared to treatment with IVIg alone.
Several reports have indicated that the chemokine receptor CCR5 and its ligands, escpecially CCL5 (formerly known as RANTES), may play a role in the pathogenesis of psoriasis. CCR5 targeted treatment could therefore be a therapeutic option for…
THypothesis: The integration of measurement outcomes in response to the PhenFlex challenge test will enlarge small, single differences by combining multiple but small effects on metabolism leading eventually to a measurable health difference before…
Failure of discontinuation of off-label antipsychotics in people with intellectual disabilities is the result of (1) subjective interpretation of behavior by caregivers, influenced by fear of worsening of behavior after drug reduction, (2) a…
Treatment with an angiotensin II receptor blocker (valsartan) stabilizes or improves the functional performance of the systemic right ventricle.
Dietary management of nutrient deficiencies with the medical food under study has a positive effect on cognitive performance in patients with prodromal Alzheimer's Disease.
The primary goal of this trial is to demonstrate that a physical activity program, which consists of an exercise program and follow-up care under supervision of a specialized physiotherapist, can prevent the frequently observed decline in global…