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Since progression from NAFLD to NASH is associated with significantly increased risk of morbidity and mortality, there is a clinical imperative to identify the NAFLD patients that rapidly progress to NASH from those who will remain in the NAFLD…
Tacrolimus (FK506) is the main immunosuppressant that is prescribed after kidney transplantation. One of the disadvantages of Tacrolimus is the small therapeutic window. In transplantation patients therapeutic drug monitoring is routinely performed…
We hypothesize that ID is an important factor in the limitation of exercise capacity in HFpEF. Systemic low-grade inflammation does not only lead to microvascular dysfunction but also to iron deficiency. Iron deficiency has a direct effect on the…
The primary hypothesis is that a novel clinical decision rule for pulmonary embolism (the YEARS strategy) is at least as safe as previous studies, yet with an increased proportion of patients safely not referred for CTPA, thus fewer false-positive D…
It is hypothesized that FAME has a positive impact on family functioning and prevents further development of parental symptoms of anxiety and depression.
To compare a ventilation strategy that uses conservative targets (PaO2 55-80 mmHg (7.3-10.7 kPa)) with one that uses conventional oxygenation targets (PaO2 110-150 mmHg (14.7-20 kPa)) for arterial oxygenation. Primary endpoint is all-cause mortality…
LRRK2 activity is linked to central mechanisms of Parkinson’s disease pathology through its role in lysosomal function, and LRRK2 kinase inhibitors, such as DNL201 (IND Number: 133665) represent a new class of therapeutics with potential to address…
Obesity is significantly associated with Atrial Fibrillation (AF), and, interestingly, if obese patients loose weight, AF dissapears in 50% of the cohort. On the other hand, adipose tissue (AT) functioning alters up weightchange. Therefore we…
Ex vivo organoid response correlates to in vivo response to standard first line treatment in mCRC patients on a metastasis level, therefore organoids can be used to predict response to therapy and select patients for a specific treatment.
By means of image-guided surgery, we can navigate the procedure by visualization of pre-operative planned MR and/or CT based 3D models and providing the surgeon with real-time feedback on the position of the surgical tool within this model and more…
The adherence of NOACs in atrial fibrillation in specific subgroups is low. Identifying these non-adherent patients in daily clinical practice is important to minimise stroke and bleeding risk. We hypothesize that NOACs are relatively often…
Gut-homing lymphocytes play a role in the development and maintainence of perianal fistula in Crohn's disease patients.
Parenting is essential for the upbringing of social, mentally and physically healthy children. Parenting interventions can support parents in this process. In general, parent training programs have a positive influence on various outcomes related to…
Postoperative change in deltoid volume following reverse shoulder arthroplasty is related to functional outcome
Rehabilitation on skates after ACL reconstruction is non inferior to current common practice.
The objective of this proof-of-concept study is to test the feasibility of the gamma-prototype of the lower limb exoskeleton XoSoft during locomotion-tasks related to daily life in stroke and incomplete spinal cord injury patients in a controlled…
Our primary objective is to compare the short and medium term (up to 6 months) clinical results in pain and function of the Bauerfeind SecuTec OA brace with only conservative treatment (no brace) in the management of patients with medial knee OA and…
there exist intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local generation of estrogens