218 resultaten
It is increasingly recognized that the immune system is a major player in this obesity related disease and the switch from benign to malign (insulin resistance and DM2) obesity is associated with changes in the immune system . In this regard, animal…
Currently, a major issue in fetuses with FGR is the diagnostic process. Children born below a certain population based centile are either constitutionally small or growth restricted. Children grown above that centile may be growth restricted…
descriptive study: data collection for norms of two novel infant assessments, i.e., the Infant Motor Profile (IMP) and the Standardized Infant NeuroDevelopmental Assessment (SINDA)
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The phenotypical and functional capacities of lymph node derived lymphocytes correlate better with biopsy-proven acute rejection after kidney transplantation than peripheral blood derived cells.
The beneficial effect of cold acclimation on insulin sensitivity is reproducible and the effect wil sustain for a longer period of time. Besides insulin sensitivity, cold acclimation also has beneficial effects on cardiovascular risk factors in type…
Primary hypothesis: Capsular repair results in less postoperative pain 12 weeks after surgery compared to capsulotomy in patients undergoing hip arthroscopy. Secondary hypotheses: Capsular repair results in less postoperative pain at all other…
Short-term (1-year) results of renal transplantation are now excellent (over 95%). Long-term (10-year and longer) results are, however, still disappointing. Where most research has focused on immunosuppression and infections, we hypothesize that due…
Our hypothesis is that HBOT decreases the incidence of wound complications of surgery following preoperative radiotherapy. Added to this, increasing the oxygen level of irradiated tissue might have a positive effect on radiotherapy response.
In 1987, MMR vaccination was implemented in the national immunization program of the Netherlands (NIP) by offering vaccinations to children at the age of 14 months and 9 years. Consequently, the annual mumps incidence decreased dramatically, not…
There is growing evidence that gut permeability (or a 'leaky gut') can be linked to metabolic health and might therefore be involved in development of metabolic disorders related to the metabolic syndrome. We hypothesize that gut…
1. To assess the safety and tolerability of different doses of a single IV injection of OTL-038 2. To assess the efficacy of ascending doses of a single IV injection of OTL-038 in detecting ovarian, renal cell or endometrial cancer during surgery by…
Reveal common mechanisms of compulsivity in OCD and GD and disorder specific characteristics of aspects that have been related to compulsivity: confidence in relation with preference for risky and ambiguous behavior, and (negative) outcome…
Exploratory study to develop hypotheses
PD-L1 is up to now the only marker that has been validated for the selection of patients treated for non-small cell lung cancer who might benefit from the treatment with PD-1/PD-L1 inhibitors. Thus far, PD-L1 status is assessed with histology, being…
Early nutrition in preterm infants is essential for growth and neurodevelopment. The last decades more aggressive nutrition has been implemented in clinical practice to ensure optimal growth and thereby optimal neurodevelopmental outcome, as…
Screening of esophageal cancer can be improved by the optical detection of field cancerization