200 resultaten
Authors hypothesized that the physical extracorporeal shock wave (ESW) stimulation will decrease the resting muscle activity of paralysed forearm muscles, reducing the degree of spasticity in surface electromyography examination as well as Modified…
Our hypothesis is that the efficacy of FMT in patients with active UC can be increased by: 1. Pretreatment with budesonide in patients with active UC, which may reduce inflammation prior to infusion of the donor feces solution. This reduced…
We expect that metformin in combination with lifestyle interventions reduces Antipsychotic induced Weight Gain compared to placebo in combination with lifestyle interventions.
Although the immunomodulatory effects of HCQ and CQ have been well described in isolated cell subsets in vitro, there is a lack of clinical studies describing the immune response after HCQ treatment in humans. In this clinical study we therefore aim…
We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…
The relaxing effect of nifedipine on the uterus will cause pain relief during a hysteroscopy.
The central hypothesis of our study is that routine postsurgical anesthesia visits reduces postoperative 30-day mortality by 30%.
Our primary hypotheses are: 1. We hypothesize that infant-father interactions in the oxytocin and vasopressin condition are characterized by enhanced stimulatory and sensitive play and increased paternal protective behavior as compared to the…
In the pathogenesis of medullary thyroid carcinoma a mutation of the RET thyrosine kinase system plays an essential role. In animal models the thyrosine kinase inhibitor imatinib showed tumor regression. So a Phase-2 study in patients with…
Ons doel is om de effectiviteit van optimaal gedoseerde MTX versus placebo te onderzoeken in patienten met recent gediagnosticeerd PMR (volgens de 2012 EULAR/ACR criteria).
Is CD35, CD21, CD55 associated With Exudative Age-Related Macular Degeneration?
PK and PD effects of JNJ-61393215
As changes in gutmicrobiota composition could play a role in the development of autoimmune diseases including hypothyroidism, we will investigate whether repetitive fecal transplantation from either allogenic (healthy) or autologous (own) fecal…
Ceftazidim as prophylaxis to reduce the incidence of Post-ERCP pancreatitis.
Primair:Het evalueren van de veiligheid en verdraagbaarheid en het bepalen van de maximale verdragen hoeveelheid van HM71224 na een enkelvoudige en meervoudige dosering in gezonde vrijwilligers.Secondary: om de farmacokinetiek (PK) van HM71224 te…
De primaire doelstelling van dit onderzoek is de beoordeling bij proefpersonen met het lange-QT-3-syndroom (LQT3) van:- het effect van oraal eleclazine op het gemiddelde QTcF-interval (in msec) overdag na 24 weken behandeling met eleclazine (…
Dit onderzoek is bedoeld om de werkzaamheid te testen van een nieuw vaccin als bescherming tegen gordelroos bij mensen die een transplantatie hebben ondergaan met stamcellen uit hun eigen bloed.
Wij willen onderzoeken of dopa-resistente en dopa-responsieve tremor bij de ziekte van Parkinson door verschillende hersengebieden geproduceerd worden. We verwachten dat de basale kernen een belangrijke rol spelen bij dopa-responsieve tremor,…
Aangezien cognitieve stoornissen het meest invaliderende aspect van schizofrenie zijn en hiervoor geen effectieve behandeling beschikbaar is, is het noodzakelijk dat er gezocht wordt naar nieuwe potentiële therapeutische targets. Recentelijk wordt…