31 resultaten
We hypothesize that in healthy individuals with Early-life stress (ELS), THC, which directly targets the endocannabinoid system, is more effective than hydrocortisone in improving stress adaptation and extinction learning in an experimental model of…
Type 2 diabetes is cause by progressive beta-cell dysfunction against a background of obesity and insulin resistance in susceptible individuals. Peroxisome proliferator-activated receptor (PPAR) gamma-mediated mechanisms are involved in the…
Perioperative magnesium infusion (maintaining a serum concentration between 1.5-2.0 mmol/L) is able to clinically significantly reduce the incidence of perioperative atrial fibrillation (POAF).
TDCS will improve ABM and improve clinical outcomes. The combination of tDCS and ABM has effects on clinically relevant outcome measures
The present study is a feasibility study. In this study we will test the feasibility of the procedures used, the compliance to the interventions, and the usefulness of intermediate outcome measures in a specific high risk group. If the results of…
The hypothesis is that magnesium oxide is effective in reducing the intrafraction motion of the prostate during radiotherapy treatment for prostate cancer.
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We hypothesize that telephone aftercare for patients of 70 years and older within 24 hours after discharge to a home setting from the ED will lead to a reduction in hospital admission, in avoidable, unanticipated hospital admissions and ED visits…
Compressive occlusal loading of a space between composite and tooth material will lead to an increase in lesion depth and mineral loss in these samples.
1. After completing real approach bias re-training, participants will show a stronger reduction in approach bias for alcohol than after placebo training (main effect 1); 2. After completing real attentional bias re-training, participants will show a…
To assess the change in arterial wall inflammation, measured with 18F-FDG PET/CT, in patients with increased CV-risk and statin intolerance due to statin-associated muscle symptoms after PCSK9 inhibition
Medication overuse headache (MOH) is a disorder that results from the overuse of analgesics, triptans or other acute headache medication. Patients overusing triptans are almost always patients with migraine as their primary headache. There is…
We expect that the participants from the experimental group are improved in terms of state measures of body image, compared to the control group.
Insomnia patients form a heterogeneous group, each phenotypes of insomnia will show different therapeutic demands.
A positive effect on mood is expected after LSD (20 µg) compared to placebo. The effect of LSD on mood is expected to differ depending on time of drug administration (morning vs evening).
We expect that tDCS will enhance speed of language recovery, resulting in improved communication, quality of life and participation - associated with decreased rehabilitation consumption and cost reduction.
1. TGC with insulin in continuous tube fed patients is superior to TGC with insulin in regularly fed patients; 2. Vildagliptin as add-on therapy to insulin mediated TGC results in less hypoglycemic episodes compared to placebo.
With postoperative minimal enteral feeding (MEF) the neonates can be fed completely enteral earlier than without MEF.
Can PBM lead to beneficial effects on the following outputs: Mood, sleepiness, subjective/objective performance, need for recovery, cortisol, sleep timing and quality, melatonin rhythms, heart rate variability, immune response.
The aim of this research project is to investigate cannabidiol as a new medicine to target the cannabinoid system in the reduction of anxiety disorder symptoms. The research question is whether cannabidiol, as an augmentation strategy of exposure…