177 resultaten
Objective: To assess the diuretic effect of three standard glasses of beer, red wine and spirits in euhydrated elderly men.
Primary objective 1. To determine the effect of food on the pharmacokinetics of buspirone administered as the Lybridos formulation Secondary objective 1. To evaluate the safety and tolerability of a single dose of Lybridos under fasted and fed…
The exposure set-up is able to achieve truly double-blind exposure conditions. The objective is to assess if people can tell if the exposure unit is on or off. The testing of our exposure unit aims at identifying and eliminating any potential…
We will investigate the effects of high dairy intake on metabolic flexibility, glucose metabolism and insulin sensitivity, which are all important characteristics of (metabolic) health. We hypothesize that high dairy intake improves insulin…
B2-agonists can increase CFTR function and improve disease parameters in patients with CF with a residual CFTR function. Multiple patient-specific parameters are important for the amount of B2-agonist induced CFTR function, measurements in organoids…
We hypothesize that there is no difference between the survival and follow of the uncemented and cemented ABG THA.
For cochlear implanted (CI) patients speech recognition in noise still remains one of the most challenging tasks. One way to improve performance in noise is to benefit from binaural hearing (hearing with two ears). For individuals with residual…
Lipolysis inhibition during endurance exercise leads to a significantly greater improvement in 24-hour glycemic control in type 2 diabetes, as opposed to endurance exercise under normal circumstances.
The primary objective of this study is to validate MRI as a functional measuring device for directly monitoring gastric emptying in vivo
In this study we will investigate whether the effects of physical activity on cognitive performance are present after short (10 minutes), medium (20 minutes) or longer (30 minutes) bouts of moderate exercise in order to establish the feasibility of…
Our hypothesis is that there is no difference in efficacy between perforation and perforation with application of one of the injection fluids. The potential health care efficiency gain consists of more homogeneity in the treatment of LE. Hereby,…
We hypothesize that bi-daily 5ml NaCl 7% nebulizations improve respiratory symptoms and quality of life in PCD patients compared to 5ml NaCl 0,9% nebulizations.
MCT is more effective than ERP, both statistically significant and clinically relevant.
It is estimated that in the Netherlands 30-40% of people who are HIV infected are unaware of this fact. When an HIV infection is detected in time, it can be easily treated. This will prevent the HIV infection becoming AIDS. Once the patient develops…
Allogeneic blood transfusions are reduced when comparing the use of an ABT system to no use of post-operative drains in patients who underwent TKA.
It is hypothesised that inhaled mannitol 400 mg b.d. will lead to a significant improvement in the absolute change in percentage of predicted FEV1 from baseline following eight-weeks of trial treatment compared to treatment with inhaled placebo b.d…
The immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae is different compared to pneumonia patients with another pathogen.
The hypothesis of this study is that dosing everolimus 5mg twice daily(BID) instead of 10 mg once daily (QD) decreases the incidence of side effects, as a result of a lower Cmax while maintaining Cmin and AUC.
PPI use during Erlotinib therapy decreases bioavailability of the latter. Since a PPI is often used during erlotinib therapy, this DDI confronts pharmacists and oncologists with major challenges. A profound solution for managing this DDI is not yet…
Of all babies that die after 25 or more weeks gestation, 40% are small-for-gestational-age (SGA). In the Netherlands third trimester ultrasonography (US) is increasingly being used to monitor foetal growth even though evidence on its effectiveness…