196 resultaten
A mathematically correct PK-PD model will be developed that describes the depressant effect of propofol on breathing with and without a background of remifentanil.
1. SMOFlipid® decreases peripheral insulin sensitivity to a lesser extent compared to the other lipid emulsions, Intralipid® and Clinoleic®, due to the lower n6/n3 ratio and the higher MCT concentration in the SMOFlipid emulsion; 2. SMOFlipid®,…
Different dietary proteins have a different effect on blood pressure-related mechanisms.
The present study will investigate how serotonin (manipulation via ATD) modulates psychological and physiological reactions to interpersonal stimuli in individuals at risk for MDD. This is relevant for several reasons: 1. The onset, severity, and…
Sensory properties of diary products predict expected satiation when test products are iso-caloric. Expected satiation will change after repeated consumption of the products when properties are not congruent with caloric content.
Based on its general pro-hemostatic potential, prothrombin complex concentrate may be effective in (completely or partially) reversing the anticoagulant effect of the new antithrombotic agents Dabigatran and Rivaroxaban.
The percentage of curatively treatable metastatic disease after surgery for primary colorectal cancer can be increased by means of optimizing follow-up of colorectal carcinoma. Intensifying the follow-up by increasing frequency of CEA measurements…
Oral and gastric stimulation both affect satiety. We hypothesize that oral and gastric stimulation increases subjective feelings of satiety and lowers subsequent food intake. In addition it is expected that subjective feelings of satiety are highest…
We hypothesize that treatment with a DPP-4 inhibitor will enhance the glucagon response to hypoglycaemia in patients with type 1 diabetes.
The protein content of a product has an influence on satiety, e.g. the higher the protein content, the lower the subsequent intake. In addition, a sensory specific satiety effect is expected, meaning that after eating a preload with a certain taste…
1. Oxytocin will mimic MDMA-induced prosocial effects; 2. Blockade of the 5-HT1A receptor will prevent occurrence prosocial effects after MDMA intake (acute, not on subsequent occasions); 3. MDMA users carrying the fast working SERT genotype variant…
Tolerance of the new paediatric sip feed is equal to the standard paediatric sip feed.
In this study, we will investigate whether formerly preeclamptic women exhibit increased angiotensin II sensitivity, which may attribute to renal dysfunction. Furthermore, we will investigate the renal hemodynamics in the short term following a…
Participation in a health check-up results in a statistically significant positive change in health-related behaviour after 6 months.
Consumption of potato products with a higher amylose/amylopectin ratio is expected to result in increased colonic fermentation as well as in lower postprandial glucose and insulin concentrations compared to the consumption of conventional potato…
To investigate the added effects of dietary sodium restriction and hydrochlorothiazide on top of ACEi, on albuminuria and blood pressure, in patients with diabetic nephropathy, and whether extracellular fluid volume is an intermediate factor in…
It is predicted that the PDE5 inhibitor vardenafil will reverse memory impairments induced by THC if the latter depend on glutamatergic neurotransmission. It is expected that the cholinesterase inhibitor rivastigmine will reverse THC-induced memory…
Isomaltulose reduces the decline in working memory and attention span in older children. This reduction in decline is also seen when lower amounts of isomaltulose are combined with a mix of minerals and vitamins.
It is hypothesized that learning with a specific kind of feedback might improve learning.
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…