We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
Bron
Verkorte titel
Aandoening
Prostate cancer
CRPC
HSPC
Metastatic prostate cancer
Ondersteuning
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
The rate of successfully cultured organoids from CTCs obtained by LA.
Achtergrond van het onderzoek
Within the CIRCLE study, large numbers of circulating tumor cells (CTC) are derived from patients with metastatic prostate cancer by leukapheresis to enable culturing of organoids as a new prostate cancer model for drug screening.
Doel van het onderzoek
We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
Onderzoeksopzet
Enrolment should be completed within 2 years.
Onderzoeksproduct en/of interventie
leukapheresis
Publiek
A.C. de Jong
Postbus 2040
Rotterdam 3000 CA
The Netherlands
Tel.: 010-7044375
a.c.dejong@erasmusmc.nl
Wetenschappelijk
A.C. de Jong
Postbus 2040
Rotterdam 3000 CA
The Netherlands
Tel.: 010-7044375
a.c.dejong@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Metastatic prostate cancer.
- Intention to start (new) line of systemic treatment.
- Written informed consent of the patient.
- Age ≥ 18 years.
- WHO performance status ≤2.
- ≥ 2 adequate peripheral veins as access point for leukapheresis.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Low CTC count.
- Patients with a known hypersensitivity to the used LA-anticoagulant (ACD).
- Current ADT
- Hemorrhage disease and/or coagulation disorder.
- Inadequate liver function.
- Inadequate renal function.
- Inadequate hematology and coagulation status.
- Use of anticoagulation at time of leukapheresis, unless medication can either be safely stopped or counteracted.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL6019 |
NTR-old | NTR6150 |
Ander register | METC // ABR-nummer : MEC-2016-449 // NL57710.078.16. |