The mean 12 months eGFR change between adult HIV-1 patients on TDF containing cART without reported NSAID/MRP4-i exposure will be greater than HIV-1 patients on TDF containing cART in the highest quartile of monthly cumulative DDD NSAID exposure (…
Bron
Verkorte titel
Aandoening
Renal dysfunction; proximal tubulopathy; HIV-1
Ondersteuning
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
The following parameter will be assessed in HIV-1 patients on TDF containing cART for at least 12 months. Monthly cumulative defined daily dose (DDD) will be calculated by using WHO definitions (22).
<br><br>
1. The difference in mean 12 months eGFR change between adult HIV-1 patients on TDF containing cART without reported NSAID/MRP4-i exposure and monthly cumulative DDD NSAID exposure (or other MRP4 inhibitors) per quartile.
Achtergrond van het onderzoek
NA
Doel van het onderzoek
The mean 12 months eGFR change between adult HIV-1 patients on TDF containing cART without reported NSAID/MRP4-i exposure will be greater than HIV-1 patients on TDF containing cART in the highest quartile of monthly cumulative DDD NSAID exposure (or other MRP4 inhibitors).
Onderzoeksopzet
Crossectional
Onderzoeksproduct en/of interventie
Observational study including a non-interventional questionnaire
Publiek
Erasmus University Medical Centre <br>
Room D-418 <br>
PO Box 2040, 3000 CA, Rotterdam
C. Rokx
Rotterdam
The Netherlands
+316 813 363 28
c.rokx@erasmusmc.nl
Wetenschappelijk
Erasmus University Medical Centre <br>
Room D-418 <br>
PO Box 2040, 3000 CA, Rotterdam
C. Rokx
Rotterdam
The Netherlands
+316 813 363 28
c.rokx@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- >18 years of age.
- HIV-1 positive.
- On TDF containing cART.
- Ability to understand and sign informed consent form prior to the initiation of any study procedures.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
-Not on a TDF containing ART.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL4485 |
NTR-old | NTR4618 |
Ander register | : MEC-2014-132. |