Casein ingested within a normal milk matrix results in a more rapid digestion and amino acid absorption, resulting in greater amino acid availability and post-prandial muscle protein accretion as compared to the ingestion of isolated casein (…
Bron
Verkorte titel
Aandoening
Sarcopenia
Ondersteuning
Onderzoeksproduct en/of interventie
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Uitkomstmaten
Primaire uitkomstmaten
fractional synthetic rate
Doel van het onderzoek
Casein ingested within a normal milk matrix results in a more rapid digestion and amino acid absorption, resulting in greater amino acid availability and post-prandial muscle protein accretion as compared to the ingestion of isolated casein (without a milk matrix)
Onderzoeksopzet
baseline
2 h
5 h
Onderzoeksproduct en/of interventie
Subjects will be randomly assigned to consume either a drink containing isolated casein or casein in the normal milk matrix. By the use of stable isotope methodology we will assess the digestion and absorption kinetics of the ingested protein source and the fractional synthetic rate (FSR) of muscle proteins in the fasting and fed state in an in vivo human setting.
Publiek
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Wetenschappelijk
Universiteitssingel 50
L.J.C. Loon, van
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Males
- Aged between 65-85 years
- Healthy, recreationally active
- BMI < 30 kg/m2
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Female
- Smoking
- Allergies to milk proteins (whey or casein)
- Arthritic conditions
- Over the counter antacids
- Diabetes mellitus type 1 and type 2
- A history of neuromuscular problems
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- Participation in any regular exercise program
- Chronic use of gastric acid suppressing medication or anti-coagulants
- Unstable weight over the last three months
- Pathologies of the gastrointestinal tract
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL4285 |
NTR-old | NTR4429 |
Ander register | METC : 13-3-063.3 |