ADMA (asymmetric dimethylarginine) plasma concentrations are higher in persons with mild renal insufficiency compared to persons with normal kidney function. ADMA plasma concentrations are inversely proportional to renal perfusion and endothelial…
Bron
Verkorte titel
Aandoening
hypertension
mild renal insufficiency
ADMA
hypertensie
milde nierfunctiestoornsisen
ADMA
Ondersteuning
P. Debyelaan 25, P.O. Box 5800
6202 AZ Maastricht
Phone: +31 43 387 7005 (secretary
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
o Basal renal perfusion measured <br>
o Fractional change in renal perfusion after
intrarenal L-NMMA infusion<br>
o Arterial en venous ADMA, SDMA
(symmetric dimethylarginine) and
L-arginine concentrations<br>
o Renal elimination of systemic ADMA,
SDMA and L-arginine
Doel van het onderzoek
ADMA (asymmetric dimethylarginine) plasma concentrations are higher in persons with mild renal insufficiency compared to persons with normal kidney function. ADMA plasma concentrations are inversely proportional to renal perfusion and endothelial nitric oxide (NO) availibility in the kidney. Medical treatment with statins and/or angiotensin II receptor blockers (ARB) will reduce ADMA plasma concentrations, improves kidney perfusion and NO availibility.
Onderzoeksopzet
- 3 weeks before renal angiography --> start medication treatment
- after 3 weeks treatment --> renal angiography with additional measurements
Onderzoeksproduct en/of interventie
- 3 weeks treatment with ARB and/or statin
- Intrarenal L-NMMA (monomethyl-L
arginine, NO synthase inhibitor) infusion
Publiek
Department of Internal Medicine <br>
P.O. Box 5800
R.A. Ronden
P. Debyelaan 25
Maastricht 6202 AZ
The Netherlands
+31 (0)43 3881432
Wetenschappelijk
Department of Internal Medicine <br>
P.O. Box 5800
R.A. Ronden
P. Debyelaan 25
Maastricht 6202 AZ
The Netherlands
+31 (0)43 3881432
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Hypertension
(Office blood pressure: >140 and/or >90 mmHg or mean ABPM blood pressure: >125 and/or >80 mmHg)
2. Age: 18-75 jaar
3. Creatinin clearance of 60-90 mL/min
(Cockcroft-Gault formule)
4. Renal angiography indicated based on the following criteria:
- Refractory hypertension
- Accelerating or malignant
hypertension
- Elevating serum creatinin after
an ACE-inhibitor or ARB
- Kidney size < 8 cm measured
by ultrasound
- Unexplained hypokalemia
- Abdominal or renal souffle
- Manifestations of
atherosclerosis elsewhere
- “Flash” oedema
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Primary kidney diseases or urological
complaints
2. Diabetes Mellitus
3. Chronic inflammatory diseases
4. Recent infections (< 3 weeks)
5. Unilateral or bilateral renal artery stenosis
6. Fibromuscular dysplasia
7. Contraindication for ARB or statin
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL1383 |
NTR-old | NTR1443 |
Ander register | : |
ISRCTN | ISRCTN wordt niet meer aangevraagd |