The primary objective is to examine the relationships between the cognitive tests results of the neuropsychological assessment and dual-task cost in elderly with cognitive impairment. The second objective is to examine differences in gait…
Source
Brief title
Condition
- Aural disorders NEC
- Dementia and amnestic conditions
Synonym
Research involving
Sponsors and support
Intervention
No registrations found.
Outcome measures
Primary outcome
The outcome variables of the 160-meter walking test whit accelerometry. Walking
speed is recorded, and foot contact moments are derived from anterior-posterior
(AP) accelerations, whereof mean and coefficient of variation (CV) of stride
times, stride frequency, consistency of timing, and long term correlations are
calculated. From AP and medio-lateral (ML) trunk acceleration patterns,
variability, regularity, long range correlations, and local stability are
calculated. All variables quantify another aspect of gait variability and
stability. The outcome parameters of the neuropsychological tests include
scores on tests for the following cognitive domains: (a) memory: word list
learning, memorizing stories and paired learning; (b) executive function:
verbal fluency, divided attention, selective attention and problem solving; (c)
language: confrontation naming; (d) visuo-spatial function: copying pictures;
and (e) attention: digit span and mental speed.
Secondary outcome
-
Background summary
Cognitive impaired elderly fall more often than cognitive unimpaired elderly.
Current evidence suggests that walking is related to cognitive function, in
particular executive function. Performing an attention-demanding dual-task
increases gait variability and walking instability compared to walking only in
elderly with cognitive impairments. These changes in performance, the dual-task
costs, are caused by competing demands for attentional resources needed for
both tasks. It is presumed and many times demonstrated that dual task cost is
closely related with executive functioning. However, research that investigates
the relationship between dual-task cost and other cognitive domains, such as
memory or language, is lacking. Thereby the double dissociation is not
completed.
Study objective
The primary objective is to examine the relationships between the cognitive
tests results of the neuropsychological assessment and dual-task cost in
elderly with cognitive impairment. The second objective is to examine
differences in gait performance between walking and dual-task walking in
elderly with cognitive impairment. Furthermore, differences in dual-task cost
between subjects diagnosed with different typeof cognitive impairment, for
example Alzheimer's disease of vascular disease, will be examined.
Study design
The present study has a cross-sectional design, because every subject is
measured once and there is no follow-up.
Study burden and risks
There are no risks for patients to participate in the present study.
Furthermore, the patient's burden is reduced to a minimum, since testing is
performed during hospital visit. The duration of the tests is about 15 minutes.
Louwesweg 6
1066 EC Amsterdam
NL
Louwesweg 6
1066 EC Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Patients will be included in the present study when they are (a) 65 years or older; (b) visit the Department of Medical Psychology of the Slotervaart Hospital for a neuropsychological examination; and (c) able to walk at least 160 meter without using any assistive device.
Exclusion criteria
Patients will be excluded for the present study when they (a) have any mobility problems due to (lateral) neurological or orthopedic disorders with function limitations of one or both legs; (b) are unable to understand and follow simple verbal instructions; or (c) have severe visual impairments.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL38819.048.11 |