No registrations found.
Source
Brief title
Health condition
multiple sclerosis, pain intensity, pain affect, mood, comorbidities, cognition, cognitive impairment
Sponsors and support
Intervention
No registrations found.
Outcome measures
Primary outcome
Each substudy (5 in total) has its own primary outcome variables;please see the 5 hypothesis
Secondary outcome
n.a.
Background summary
Summary
Pain expereince in patients with multiple sclerosis is very known phenomenon. However, no studies have been performed so far that examined possible alterations in pain experience when patients with multiple sclerosis become progressively cognitively impaired. Consequently, in cognitively impaired patients, we wish to examine the relationship between pain, mood, other comorbidities, cognition, and motor activity.
Study objective
The following hypotheses will be examined:
a. patients with multiple sclerosis who become cognitively impaired may experience an increase in pain experience (due to white matter lesions)
b. hyperesthesia is known to be predictive of central neuropathic pain. But could also hypesthesia be a predictor of central neuropathic pain
c. patients with multiple sclerosis suffer from comorbidities. It is hypothesized that particularly the affective aspects of pain show a relationship with comorbidities
d. It is hypothesized that there is a close relationship between a decline in motor activity, pain, and cognitive functioning in patients with multiple sclerosis
e. It is hypothesized that there is a close relationship between pain, motor activity and sleep in patients with multiple sclerosis
Study design
There was only one moment of measurement (it is an observational study).
Intervention
n.a.
van der Boechorststraat 1
Amsterdam 1081 BT
The Netherlands
0031-20-5988761
eja.scherder@vu.nl
van der Boechorststraat 1
Amsterdam 1081 BT
The Netherlands
0031-20-5988761
eja.scherder@vu.nl
Inclusion criteria
patients with multiple sclerosis
Exclusion criteria
patients with a psychiatric history, focal neurological disorders, brain tumor, stroke, and alcohol abuse
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL6337 |
NTR-old | NTR6653 |
Other | VUMC Medische Ethische Commissie : A2017.142 |