No registrations found.
Source
Brief title
Health condition
Invasive aspergillosis
Sponsors and support
Intervention
No registrations found.
Outcome measures
Primary outcome
The accuracy with which patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls can be discriminated from each other with exhaled breath analysis using among other techniques GC-MS, as measured by the values of the sensitivity, specificity and accuracy.
Secondary outcome
N.a.
Background summary
Study objective: to establish the accuracy with which Exhaled Breath Analysis can discriminate patients with invasive pulmonary aspergillosis from controls.
Design: single center pilot study, prospective cohort.
Cases: neutropenic patients with probable or proven invasive pulmonary aspergillosis, according to the EORTC/MSG criteria.
Controls: neutropenic patients with fever but without any sign of aspergillosis.
Study objective
To establish the accuracy with which Exhaled Breath Analysis can discriminate patients with invasive pulmonary aspergillosis from controls.
Study design
Patients will be measured only once, in case of and at the moment that they undergo a full diagnostic work-up for invasive pulmonary aspergillosis.
Intervention
Exhaled breath sampling.
Inclusion criteria
Patients, aged 18 or older, that will undergo treatment for a hematological malignancy expected to result in grade 4 neutropenia for more than 7 days, e.g. hematopoietic stem cell transplantation or induction/consolidation treatment for acute myeloid leukaemia.
Exclusion criteria
Previous invasive pulmonary mycosis.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL8774 |
Other | METC AMC : - |