No registrations found.
Source
Brief title
Health condition
The study focuses on six primary research areas: (1) maternal health, (2) growth and physical development, (3) behaviour and cognitive development, (4) asthma and allergy, (5) diseases in childhood and (6) health care.
Sponsors and support
Organization for Health Research and Development (ZonMw) and the Ministry of Health, Welfare and Sport.
Intervention
No registrations found.
Outcome measures
Primary outcome
The study focuses on six primary research areas: (1) maternal health, (2) growth and physical development, (3) behaviour and cognitive development, (4) asthma and allergy, (5) diseases in childhood and (6) health care.
Secondary outcome
NA
Background summary
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging (MRI) and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
Study objective
The overall hypothesis of this study is that exposures in early life (fetal period and early childhood) are associated with health outcomes in later life.
Study design
Pregnancy
Birth
Infancy
Childhood (5 and 9 years)
Adolescence (13 and 16 years)
Intervention
None, observational cohort study
P.O.Box 2040
Rotterdam 3000 CA
The Netherlands
+31 10 70 43405
generationr@erasmusmc.nl
P.O.Box 2040
Rotterdam 3000 CA
The Netherlands
+31 10 70 43405
generationr@erasmusmc.nl
Inclusion criteria
Pregnant women living in Rotterdam, the Netherlands, with a delivery date between April 2002 and January 2006.
Exclusion criteria
None
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL6484 |
NTR-old | NTR6671 |
Other | MEC-2012-165, NL40020.078.12; MEC 198.782/2001/31 : Erasmus MC |