36787 results
To screen two different formulations of the recombinant malaria vaccine PfLSA-3-rec, one adjuvated with aluminium hydroxide and one with Montanide Isa 720, by assessing the safety and immunogenicity (phase I) profile of each formulation in humans,…
The objective of this study is to assess the difference in micromotion of the Exeter hip prosthesis, using two different bone cements. We hypothesise that the newly marketed bone cement Refobacin- gentamycine has the same in vivo properties as the…
Primary study objective:The primary objective of this study is to evaluate the clinical outcome of dual-chamber ICD therapy with minimized ventricular pacing compared with single-chamber device therapy with settings which are common in clinical…
Primary* To evaluate whether the efficacy of nilotinib is superior to the control arm (as measured by progression free survivalSecondary* To compare the response rate, and time to response, duration of response, and time to tumor progression of…
Evaluate iron metabolism, erythropoiesis and hemoblobin level periooperative in patients treated with postoperative intravenous iron injections compared to controls.
To obtain robust evidence for activity-dependent CB and depolarizing CB in CIDP or MMN. This may reveal specific mechanisms of axon loss and provide a rationale for additional treatment aimed at prevention of irreversible axon loss.
To assess whether the non-invasive duplex method can reliably determine diameters and flow characteristics in the LIMA origin of LIMA-LAD versus Y-bypass grafts late after CABG in relation to-the number of distal anastomosis-the adaptation to…
1. Is there a difference in clinical and/or functional outcome between patients older than 60 years undergoing unicompartmental or total knee arthroplasty.2. Is there a relationship between the degree and location of preoperative arthroscopic…
The following hypotheses will be tested:Hypothese a: Remifentanil PCA gives a better labour satisfaction than pethidine/meperidine i.m.Hypothese b: Remifentanil PCA gives a better pain-relief during labour, than pethidine/meperidine intramuscularly.…
The purpose of this study was:1) to assess the postoperative complications and fracture healing in patients after posttraumatic distraction osteogenesis.2) to assess the degree of the degree of function of the lower extremity upon distraction…
In this trial we will investigate the following hypothesis:- Uremic vasculopathy develops, not only in large and medium sized conduit vessels, but also in the microcirculation.- There is a relationship between the rate of microcirculatory…
Aim of this project is to diagnose hearing impairment, and underlying disorders in speech perception and production, and to develop and implement adequate intervention techniques, which are subsequently evaluated. The ultimate goal is to prevent…
Is the application of allogeneic fibrin sealant in CABG surgery feasible and effective in stopping bleedings/restore hemostasis after restoring the blood flow?
To identify factors that have an influence on the reproductive decision-making for a subsequent pregnancy of women having a child with congential anatomical anomalies.
Detection of High Intensity Transient Signals as hemodynamic parameter in patients undergoing aortic valve replacement
To determine the quantitative distal femoral bone resorption from the expected stress shielding effect of the femoral component in patellofemoral arthroplasty.
To gain understanding about the changes in intracranial hemodynamics after carotid endarterectomy. To improve the early detection of an imminent hyperperfusion syndrome.
The primary objective of this study is to demonstrate the superior antiviral efficacy of the combination of peginterferon alpha-2a plus telbivudine vs peginterferon alpha-2a monotherapy as demonstrated by HBV DNA non-detectability using the COBAS…
The aim of this project is to collect new normative data for the Dutch children, for both parts of the M-ABC2. The opportunity will also be taken to extend the age range of the test down to 3 years and up to 16 years. Also the reliability and the…
Primary objective:* Evaluate long-term effect of tolvaptan in ADPKD through rate of renal volume change(%) for tolvaptan-treated compared to placebo-treated subjects.Secondary objectives:* Evaluate long-term efficacy of tolvaptan in ADPKD through a…