36845 results
The objective of the PoCoMiMo study is to compare the abundance, and hepatic clearance of microbiota-derived molecules in the portal venous circulation between patients suffering from a primary hepatic malignancy versus those with pancreatic cancer…
The main objectives of this study are to confirm the long-term safety, performance, and clinical benefits of the G7 Acetabular Shells when used with the Vivacit-E and Longevity HXLPE liners and instrumentation in primary and revision total hip…
Objective: The main objective of our study is to examine whether we can use the IT (as determined by visual irritation grading scale after SLS patch test) to predict HS formation after reduction mammaplasties. The secondary objectives consist of…
Primary and Secondary: To assess cardiovascular function and the presence and magnitude of myocardial injury using echocardiography and cardiac magnetic resonance (CMR) imaging, among community-dwelling individuals who recovered from Covid-19…
1.To investigate COVID-19 vaccine responses of the standard schedule of 2 vaccinations with the Moderna mRNA-1273 vaccine (primary schedule) in patients with hematologic diseases, in particular those patients who are considered immunocompromised,…
To establish baseline predictive factors for acute and late lumen growth after successful opening of chronic total occlusions. Secondary objectives are:1) Identifying the relation between change in absolute microvascular resistance and late change…
To compare the efficacy, side effects and therapy compliance of intermittent (three times a week) versus daily oral iron supplementation for anaemia in pregnancy attributed to iron deficiency.
The aim is to investigate whether it is feasible to perform a 12-weeks nutritional intervention study in NSCLC patients on PD-1 ICI, and to effectively assess their nutritional, immune, and microbial status, with the intention to use this…
The goal of this study is to obtain insight into possible differences in macrophage and monocyte populations in uncomplicated pregnancies and pregnancies complicated by FGR.
The present study aims to assess the effectiveness of a religion-adapted CBM intervention compared to a standard, non-religion CBM intervention, and sham intervention based on approach bias modification (ApBM).
The purpose of this study is to investigate how quickly and to what extent RO6868847 is absorbed, distributed, metabolized (broken down), and eliminated from the body (this is called pharmacokinetics). A very small part of the study compound RO…
Primary objectiveThe key objective is to examine the anti-body immune response to SARS-CoV-2 vaccination in shift workers, compared to dayworkers, Secondary objectives:• To tinvestigate whether sleep duration, independent of circadian misalignment,…
The primary objective is comparison of the CYP3A4 activity in medically castrated patients with prostate cancer with the CYP3A4 activity of male patients with other types of solid tumours. To evaluate the CYP3A4 activity, the PK of the CYP3A4…
To assess the PK/PD relationship of prednisolone regarding toxicity as clinical outcome in paediatric patients with autoimmune or autoinflammatory diseases.
To evaluate the duration of admission, feasibility, patient satisfaction and complication rate of vNOTES hysterectomy with BSO and compare it with laparoscopic hysterectomy with BSO in case of clinical stage 1 low grade endometrial cancer.
To collect prospective clinical and molecular data on the phenotypical characteristics of patients with atopic dermatitis (AD) receiving standard care targeted systemic treatment.
To investigate whether treatment of dystonia causing varus tilt of the hindfoot in Parkinson*s disease is more effective when botulinum toxin type A is combined with complementary functional gait training compared to botulinum toxin type A treatment…
The aim is to evaluate long-term (+/- five years post-intervention) follow-up results of a previously completed study that investigated the effect of a three-component (diet, exercise, cognitive behavioural therapy (CBT)) lifestyle intervention with…
To establish the effectiveness and safety of EUS-CD as the primary drainage strategy in patients with malignant distal biliary obstruction.
Primary Objective: 1. To determine the effectiveness of a personalised, holistic 24-week digital lifestyle programme in achieving diabetes type 2 (T2DM) remission independence from blood glucose-lowering medications, in a Dutch population, in…