29306 results
Primary objective: The primary objective of the study is to evaluate the dose-response of tofacitinib in inducing clinical remission in subjects with moderate to severe Crohn*s disease and to select effective doses. Secondary objectives: -To…
The present research protocol aims at the development and implementation of a valid self-report instrument for suicidality amongadolescents. The instrument needs to be invariant for ethnicity and needs to register fluctuations in suicide risk and…
We will examine effectiveness of the internet-based self-help intervention compared to a waiting list control condition on (1) reduction of depressive and anxiety symptoms post intervention and 6 weeks post-partum and (2) improvement in perinatal…
The present protocol addresses these issues, with a systematic approach where we first assess optimal settings for BCI, and then test the quality of BCI application in adequately sized groups of subjects. The whole project is aimed at obtaining a…
In our current study we would like to evaluate a newly developed surgical platform for minimal invasive cardiothoracic surgery: the soft tissue expander. Main objective of the study is to determine the feasibility of creating a trans tissue expander…
Effectiveness: To provide valid scientific evidence that use of the TactiCath® Set is an effective treatment for symptomatic paroxysmal atrial fibrillation (PAF).Safety: To provide valid scientific evidence that use of the TactiCath® Set is safe as…
1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…
Obtain information regarding the movement abilities and muscle strength in persons with several neuromuscular diseases, which can be used to develop a motion controlles arm suport for daily use and training of arm function.
There are four main objectives in this research project, belonging to two different parts of the study. Part 1 comprises objectives 1 and 2:1. Determine the electrode discrimination abilities of prelingually deafened adult CI users in order to…
Primary: Safety and tolerability of fingolimod 0,5 mg.Secundairy: Efficacy and quality of life.
The primary objective of this controlled clinical study is to evaluate the clinical effect of decontamination of the implant surfaceduring the surgical treatment of peri-implantitis using a 35% phosphoric acid gel or saline.The secondary objective…
1. Validation - of an independent geneset - of TLA technology as a new DNA diagnostic test for complete sequencing of selected genes.2. The search for structural chromosome changes in patients with ROW disease who where tested negative for mutations…
The study is intended to provide insight into the clinical feasibility of the Exilis* system as a therapy for obesity, including:* Providing initial human safety data on the Exilis* system, * Gaining an understanding of how to individually titrate…
Primary objective:To determine which anthropometric parameters, LBM, total body weight (TBW) or BSA correlates best to docetaxel exposure (AUC). Secondary objectives:To determine if occurrence of docetaxel toxicity can be related to dose/LBM.To…
The primary aim of this study is to validate the paradigms designed to investigate the effects of social stress and reward on in healthy individuals. This will allow us to evaluate and optimize the experimental paradigms in terms of their design,…
The primary objective of this study is to investigate equivalence of weight gain from randomisation until the age of 17 weeks in infants receiving the test product compared to infants receiving the control product. Secondary objectives of this study…
This is a feasibility study of the Balloon-based Focal Cryoablation System to assess safety and performance in patients with a Barretts esophagus
Objective of this study is to determine validity, test-retest reliability and discriminant ability of the Mr Cube system to assess coordination and proprioception of the knee joint in patients following ACL reconstruction, patients with patellar…
To evaluate the effects of mild, moderate or severe hepatic impairment versus normal hepatic function on the pharmacokinetics of TKI258 in patients with advanced solid tumor
The primary aim is to investigate the effects of attentional focus manipulation on the performance of a repetitive leg movement task under single and dual-task conditions in ABI patients. Furthermore, it will be investigated to what extent the…