22420 results
Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…
1. To characterize the efficacy of topical Fibrocaps plus gelatin sponge, as compared to gelatin sponge alone, in surgical subjects when control of mild to moderate bleeding by standard surgical techniques is ineffective and/or impractical2. To…
The primary objective of this study is to : Assess the hemodynamic profile of Riociguat in patients with symptomatic pulmonary hypertension associated with left ventricular systolic dysfunction The secondary objectives of this study are to : -…
Our proposed randomized controlled trial is the first making this head-to-head comparison in a *real life* primary care setting in the Netherlands. The primary research question is: does a 12-week combination therapy of open label varenicline and…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
- To investigate the safety and tolerability of posaconazole IV Solution (the test medication).- To study how the test compound posaconazole (the test medication) is absorbed, broken-down and excreted by the body. - To study the effect of the test…
Will a sleep training consisting of CBT in a chronic, psychiatric population with depressive disorder and insomnia lead to a decline of sleeping problems and a increase in sleep quality? Will the results from a normal and non chronic population will…
To determine the best dose escalation scheme of dipyridamole added to acetylsalicylic acid, based on the side-effect headache, in patients starting secondary preventive therapy for stroke
Primary Objective: To assess immediate and long-term effects of Mindfulness-based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) in reducing depressive symptoms in patients with diabetes. Regarding immediate effects, we expect that…
The purpose of this study is to investigate the clinical performance of Thoraflex in the treatment of subjects with aneurysm or penetrating ulcer of the descending thoracic aorta.The primary objective of this study is to demonstrate the safety and…
The primary objectives of this study is:* To determine the safety and tolerability of rhHNS via ascending doses administered via a surgically implanted intrathecal drug device (IDDD) once monthly for 6 months, in patientswith MPS IIIA.The secondary…
Primary objectiveTo determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of LEQ506 when administered orally on a continuous daily dosing schedule.Secondary objectives* To characterize the safety and…
Primary objective: To demonstrate the superiority of QVA 110/50 µg compared to both QAB149 150 µg and NVA237 50 µg in terms of trough FEV1 (mean of 23 h 15 min and 23 h 45 min post-dose) following 26 weeks of treatment in patients with moderate to…
PRM-151 is being developed for potential therapeutic use to prevent, treat and reduce fibrosis. This study will provide an assessment of the safety, tolerability, pharmacokinetics and pharmacodynamics of PRM-151 after administration of ascending…
Primary:- to investigate the safety and tolerability of the study drug after multiple oral dosing in healthy volunteersSecondary:- to investigate the effect of the study drug on potassium clearance upon oral potassium challenge after multiple oral…
Our objective is to evaluate the patency of paclitaxel coated balloons in hemodialysis patients presenting at the radiology department more than once a year with repetitive severe stenoses of their fistula, and compare the results with primary…
Primary objective: The primary objective of the study is to determine the effect of concentration/meditation on the innate immune response induced by a lipopolysaccharide (LPS) challenge. Secondary Objective(s): There are two secondary objectives:1…
The objectives of this phase of the study are to confirm the efficacy of IV relaxin, in addition to standard therapy, in improving symptoms of heart failure, dyspnea, and in preventing intermediate term re-admission for HF or renal failure and…
Primary ObjectivesThe primary objective is to explore the tolerability, safety and treatment response (maintained/improved efficacy), based on total Positive and Negative Syndrome Scale (PANSS) score, of a transition to flexibly dosed paliperidone…
The purpose of the present proposal is to improve care to children with asthma by including regular assessments of non-invasive inflammatory markers during the management of asthma. In this case, treatment is also guided by inflammatory markers (…