850 results
To establish the test-retest reliability of the 13C-PBT for measuring Phe hydroxylation in patients with PKU.
This study is performed to investigate the optimal strategy for maintaining quality of life and improving survival in elderly patients (65 years or older) diagnosed with primary GBM. Primary endpoints of the study are: 1) Proportion of patients with…
Primary objective: Inpatient Group: The primary objective of the research with the inpatient group is to assess whether there is a treatment effect in cognition (at T2) compared to baseline (T1) using conventional rehabilitation, as compared to…
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…
The objective of the HORIZON trial is to demonstrate and provide long-term clinical data on safety and performance of the Qmedics EXIST NiTi Stent System type FLEX & PULL for treating de novo or re-stenotic symptomatic atherosclerotic…
1. To determine biomarkers of response and non-response to treatment for active SLE in a prospective study where patients will be allocated to therapy according to current clinical practice and the EULAR guidelines (response biomarker study; 3TR SLE…
The main goals of this study are to study the effects of VHPSD ablation on the duration of a pulmonary vein isolation procedure, and on transient (edema) and persistent (fibrosis) effects of VHPSD ablation in the left atrial wall.
Study the concordance rate of SLN identified using MSOT and ICG versus the standard of care with Tc99m and lymphoscintigraphic imaging.
To test if a CRT-targeted resuscitation based on clinical hemodynamic phenotyping can improve a hierarchical clinical outcome - mortality, time to cessation of vital organ support, and length of hospital stay, all within 28 days - in septic shock…
Determine speech understanding in noise with the AB*s bimodal BF directional hearing technology.
The primary goal of this study is to investigate the effects of belimumab on the composition of lymph nodes and the inflamed synovial tissue as well as (subsets of) immune cells in the peripheral blood. In addition, we will identify immunological…
The primary objective is to compare the effectiveness of ambroxol versus placebo on the MDS-UPDRS part III motor sub-score in the *practically defined OFF-medication state* in patients with moderate PD, carrying a GBA mutation. The hypothesis is…
The VOLT AF First-in-Human (FIH) study will collect feasibility data to show that the Volt PFA System functions as intended in a clinical setting and to demonstrate acute safety and effectiveness for the treatment of symptomatic, recurrent…
The purpose of this study is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft System versus Gore Excluder/Excluder Conformable AAA Endoprosthesis in subjects with AAA.
To assess the safety of a novel care pathway in which patients, with a predicted mild course of acute pancreatitis, are discharged early with remote home monitoring.
The purpose of this study is the evaluation of InPen* with InPen* 2.0 app and Guardian* 4 system in adult patients with type 1 diabetes for the design of a future study.
To improve the pathological response rate according to Miller and PayneTo improve quality of life including cognitionTo determine the effect of FMD on local tumor immunity
- special attention for the development and harmonization of the pre-analysis of liquid biopsy, for blood as well as urine, andnext to this for ctDNA- special attention for the detection of PIK3CA mutations in blood and urineSimultaneously also the…
Because experimental evidence suggested the possibility to measure paratonia through muscle activity, the primary aim of this study is to develop an objective non-invasive tool based on surface electromyography (sEMG) to quantify the presence and…
Primary Objective: We aim to create a prediction model to predict islet graft function at 3 months post-transplantation, using early islet graft function assessed in the first week after islet transplantation.Secondary Objective(s): - To determine…