1599 results
Actualize, replicate and extend the data of NEMESIS-1 with regard to the prevalence, incidence, course and consequences (functioning, mental health care use and costs) of psychiatric disorders among the general population of the Netherlands.…
PRIMARY OBJECTIVESthe assessment if survival in grade III glioma without combined 1p/19q loss is improved by - daily temozolomide chemotherapy during radiotherapy - the administration of temozolomide after the end of radiotherapy SECONDARY…
To determine the maximum tolerated dose (MTD), dose limiting toxicities (DLT), and optimal dose of docetaxel that can safely be administered to patients with cancer in a weekly schedule. amendment 1The objective of the first amendment is to…
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
The main objective of this study is to assess whether ICD therapy in dialysis patients reduces sudden (arrhythmogenic) cardiac death. The first secondary end point is to compare total mortality death between the two groups. An other is to evaluate…
Various brain areas play a crucial role in both pain and cognition, supporting the existence of a close relationship between pain and cognition. Consequently, it is important to examine whether pain experience changes at the moment the patient shows…
Primary objective: To determine if apixaban is noninferior to warfarin (INR target range 2.0-3.0) in the combined endpoint of stroke (ischemic or hemorrhagic) and systemic embolism, in subjects with AF and at lease one additional risk factor for…
The primary objective of the study is to compare the efficacy of intravenous immunoglobulin product with the efficacy of antibiotic treatment in patients with recurrent respiratory infections and IgG-subclass deficiency and/or selective anti-…
ObjectiveEvaluation of the application of cultured autologous keratinocytes in combination with a meshed split skin autograft to improve burn wound healing
To assess whether a combination of ciprofloxacin and adalimumab is more effective than adalimumab alone.
To study the efficacy of low dose Lenalidomide maintenance combined with bortezomib treatment following non myeloablative Allo-SCT on Event Free Survival.
Objective: Does minimal invasive total knee replacement has (at least) comparable or better results to conventional total knee replacement if looked at functional recovery, complications and pain.Amendement 1: measure the accuracy of the cementing…
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
In the present study we will assess the associations between the nutritional status of Hindustan pregnant women on the one hand and anthropometric and metabolic parameters of their neonates on the other hand.
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
the objective of the current study is to evaluate the safety and efficacy of enzyme therapy in the Dutch population of patients with MPS I, II and VI; to compare this to the natural course of these diseases; to make an inventory of the direct and…
The objective of the study is to improve quality of life of patients with Hepatitis C, by teaching patients psychological skills that aid in coping with the consequences of the disease.
In the first place, we will collect tissues from over-reacting patients, including a thorough quality assurance program. Thereafter, we will identify the gene profiles of the patients that exhibit extreme radio-sensitivity without known hereditary…
The objective is to evaluate and compare the outcome of conventional open or arthroscopic rotator cuff surgery, by means of clinical scores and biomechanical studies (range of motion, scapulohumeral rhythm, muscle activation patterns).
The primary objective of this study is to demonstrate that the efficacy of rivaroxaban, a direct FXa inhibitor, is non-inferior to that of dose-adjusted warfarin for the prevention of thromboembolic events in subjects with non-valvular atrial…