3809 results
The aim of the study is to understand the nutritional status of people with complex multiple disabilitiest through measurement of body composition and nutritients.The primary objective of the study is:What percentage of people with complex multiple…
The objectives of this proposal are twofold. First, we intend to test the feasibility of the new concurrent fMRI/TMS setup on real brains of a small group of healthy volunteers. That is, can we indeed evoke fMRI BOLD responses in several functional…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
The goal of the study is to investigate the difference between heart rate variability in patients with overactive bladder and patients with stress incontinence without overactive bladder, and also the difference in heart rate variability with empty…
First, to determine the extent to which microcirculatory perfusion defects occur during clinical kidney transplantation. Second, to study the relationship between these events and kidney function, inflammation and renal cellular injury. Third, to…
The aim of this project is to gain insight in which somatic, cognitive and psychosocialfactors contribute to preservation of functioning, in order to identify older people with potentialrisk of functional decline in an early stage and develop…
In the current study, we want to determine and correlate the results of both perfusion capacity (with MR imaging) and sublingual glycocalyx dimensions in a) patients with proven obstructive coronary artery disease and b) patients with angina but…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
Primary Objective: • To compare urinary concentrating capacity in ADPKD patients with healthy subjects and patient with IgA- or membranous glumerulopathy.Secondary Objectives:• To compare urinary concentrating capacity in ADPKD patients with an eGFR…
The main goal of this project is the elucidation of the mechanism underlying the paternal inheritance seen in SDHD- and SDHAF2-related paraganglioma. The results of this project should aid us in the identification of the *modifier* gene, essential…
Primary objectives:1a. To determine the severity and course of obstructive sleep apnea in children with congenital mandibular hypoplasia (both isolated and syndromal).1b. To determine the growth pattern of the lower face in relation to the upper…
The aim of this study is to define the specific changes in skeletal muscle composition and function, systemic inflammation and nutritional intake and physical activity levels, during cancer treatment. To investigate this, we will include 13 female…
To investigate the presence and extent of small airways disease in subjects with asymptomatic AHR, patients with asthma and non-AHR controls. Specific research questions:1) Do subjects with asymptomatic AHR have less small airways disease than…
To investigate whether elderly individuals lose muscle mass at a greater rate than young individuals during 5 days of one legged knee immobilization, and whether dietary protein supplementation can alleviate such muscle loss in the elderly.
Primary Objective: To determine the prevalence of endo- and extranasal deformities, problems with nasal functioning and satisfaction with nasal appearance in patients with TCS.Secondary Objective: To adjust and improve the treatment of patients with…
Primary Objective: To examine which subregions of the hippocampal formation on 7 Tesla MRI are most affected in patients with early Alzheimer*s disease compared with older persons with normal cognition. Secondary Objectives:a) To explore risk…
The objective of this study is to determine the role of dopaminergic neurotransmission in the basal ganglia in response regulation.The outcome of the proposed studies is intended as proof of concept for our future research initiatives on the…
This study aims at understanding the circadian disruption in chronic hemodialysis patients and provide a molecular basis for the etiology of sleep-wake cycle disturbances. The hypothesis that the circadian clock is disturbed in chronic hemodialysis…
The main aim of this study is to investigate directed forgetting of emotional versus neutral words in patients with fibromyalgia compared to healthy controls. Secondary objectives are to examine potential associations between directed forgetting and…
To determine, in patients registered at our hospital having CRPS (types I) at the leg, the percentage of patients having clinical features compatible with SFN and compared to the unaffected leg (in unilateral cases) to determine possible focal or…