27 results
Primary Objective:-Evaluate tumour detection sensitivity and specificity with the following image enhancement modalities:1 *narrow-band imaging*, (NBI)2 *near-infrared indocyanin green imaging*, (ICG)3 *5-aminolevulinic acid fluorescent imaging*, (5…
Based on the identified gaps in the evidence underlying the clinical guidelines on non-specific low back pain of the Dutch College of GPs and the recent findings of the Australian PACE study the objectives of the present study are: 1. What is the…
To investigate the analgesic profile of different classical and non-classical analgesic compounds using a battery of pain tests (PainCart) in healthy subjects compared to a negative control.Secondary:- Investigate the association between subjective…
To determine which advanced image enhanced modality is the most feasible for the detection of endometriosis lesions, with respect to the specificity and sensitivity of the investigated modalities. To determine which imaging modality reveals more…
Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…
The main objective of this study is to investigate which premedication scheme reduces best the pain during and after a BMAB and reduces best the fear for a possible next BMAB. Other objectives are the influence of the different medication schemes on…
To estimate the onset of analgesia of the oxycodone IR formulation OxyNorm Instant using an acute pain model in healthy volunteers.
Study the association between timing of the use of paracetamol during hepatitis B vaccination and the development of an antibody response in health care students who are routinely vaccinated with hepatitis B vaccine.
To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.
Phase 1: Investigate a possible suppressing effect of prophylactic paracetamol use in adults on the response of the hepatitis B vaccination. Phase 2: Study the association between timing of the use of paracetamol during hepatitis B vaccination and…
The objective of the proposed pilot study is to explore acceptability and feasibility of structured and adequate symptomatic treatment in adult women with uncomplicated UTI.
- To educate adolescents about clinical drug studies by involving them as project team members and participants in an experiment with negligible risk and minimal burden;- To investigate the effects of paracetamol on nociception in adolescents; - To…
The primary objective is to assess whether there is a clinical relevant effectiveness of NSAID compared to Paracetamol over a period consistent with the Dutch guidelines for general practitioners in new consulters with knee OA in general practice.…
Ergonomics and function of the imaging system - the NIRF imaging system should not interfere with the standard Sentinel Lymph Node mapping procedure and used safely by the surgeon while detection of ICG takes place. Duration: 1,5 hour clinical…
To test an intra-operative fluorescent camera system with a fluorescent optical agent in detection of the sentinel lymph node. This will be compared to the standard method with radiocolloid and patent blue.
This study aims at evaluating whether indocyanin green (ICG) enhanced intra-operative near-infrared fluorescence (NIRF) imaging is as good as or even better than the standard technique (technetium-99 labeled colloid and Patent Blue) in detecting…
To investigate the postoperative pain, compliance, satisfaction in the three different groups of postoperative analgesia and a possible interaction.
The objective of the current study is to compare three different strategies of pain management in patients presenting to an emergency department and to a general practice with acute musculoskeletal syndromes (defined as musculoskeletal complaints…
Aim of the present study is to investigate if a combination of a radioactive and fluorescent tracer can increase the sensitivity and specificity of the SLNM technique in colon and rectal cancer by utilizing the radioactive component for preoperative…
The overall aim of this study is to achieve optimal QoL and ADL function in long term care falicity (LTCF) residents with moderate to (very) severe dementia and moderate to low QoL, and to achieve less care dependency, less pain, challenging…